IL-4 and IFN-γ As Immunologic Predictors of Response to HPV Immunotherapy in Warts
试验速览
- 阶段
- 不适用
- 状态
- 已完成
- 入组人数
- 80
- 试验地点
- 1
- 主要终点
- Change of IFN-γ and IL-4 levels
研究概览
简要总结
In the present study the investigators assessed the invitro role of IL-4 and IFN-γ in predicting the response to bivalent HPV vaccine after whole blood stimulation
详细描述
40 Patients and 40 controls are enrolled in the study. Participants suffer from chronic recurrent cutaneous and genital warts. Blood samples were withdrawn then whole blood cultures are prepared. Cultures are stimulated with bivalent HPVvaccine. IL-4 and IFN-γ measurement in culture supernatants by ELISA. IL-4 and IFN-γ are investigated to predict the therapeutic response to bivalent HPV vaccine immunotherapy in warts.
研究设计
- 研究类型
- Observational
- 观察模型
- Case Control
- 时间视角
- Prospective
入排标准
- 年龄范围
- 36 Months 至 —（Child, Adult, Older Adult）
- 性别
- All
- 接受健康志愿者
- 否
入选标准
- •Patients with recurrent and recalcitrant cutaneous and anogenital warts.
排除标准
- •History of allergy to the HPV vaccine
- •Active viral, fungal, or bacterial infections
- •Immunosuppressive diseases or drugs.
- •Autoimmune diseases, or other systemic diseases, e.g., hepatic, or renal disorders, diabetes, meningitis or convulsions
- •Skin allergies
- •Pregnancy and lactation
- •Earlier wart treatment at least one month before enrollment.
研究组 & 干预措施
Cases
Patients having multiple recurrent and recalcitrant cutaneous and genital warts
干预措施: IL-4 and IFN-γ measurements (Biological)
Controls
Healthy volunteers matched for age and sex
干预措施: IL-4 and IFN-γ measurements (Biological)
结局指标
主要结局
Change of IFN-γ and IL-4 levels
时间窗: 48 hours
Quantitative measurement of IFN-γ and IL-4 in culture supernatants
次要结局
- Change in the size of warts(6 months)
研究者
Noha M Hammad, MD
Principal investigator
Zagazig University