NCT05068713已完成3 期
High Versus Low Blood-Pressure Target in the Post Operative Care of Liver Transplantation
适应症
试验速览
- 阶段
- 3 期
- 状态
- 已完成
- 入组人数
- 174
- 试验地点
- 2
- 主要终点
- incidence of Acute Kidney Disfunction
研究概览
简要总结
LIVER PAM
A randomized, controled, open and unicentric trial comparing high (MAP 85-90 mmHg) and low (65-70 mmHg) target of mean arterial pressure in the first 24 hours after liver transplantation.
研究设计
- 研究类型
- Interventional
- 分配方式
- Randomized
- 干预模型
- Parallel
- 主要目的
- Treatment
- 盲法
- Single (Outcomes Assessor)
入排标准
- 年龄范围
- 18 Years 至 —（Adult, Older Adult）
- 性别
- All
- 接受健康志愿者
- 否
入选标准
- •Older than 18 y
- •Admitted in the ICU for a post operative care after liver transplant
排除标准
- •Consent refusal
- •Liver transplant due to acute liver failure
- •Renal transplant ( Previous or concomitant)
- •Refusal from the healthcare provider responsible for the patient
- •Renal substitution therapy in the prior 15 days
- •Pregnancy
- •Re-Transplant (Liver transplant in the previous 6 month)
- •Hepatorenal syndrome current treatment (Use of terlipressin + Albumin)
- •Refractory and persistent shock during or after transplant
结局指标
主要结局
incidence of Acute Kidney Disfunction
时间窗: 7 days
Incidence of acute kidney Disfunction according to kdigo criteria.
次要结局
- Days alive and out of hospital in 28 days(28 days)
- re-transplant(28 days)
- Lenght of Hospitay Stay(28 days)
- Substitutive Renal Therapy(7 days)
- MAKE28(28 days)
- Mortality(28 days)
- Need of Transfusion(7 days)
- Postoperative Major bleeding in 7 days(7 days)
- Days Alive and free of renal disfunction(28 days)
- Acute kidney insufficiency according to Urinary NGAL on d0 and D2(0d and 2d)
- Liver graft primary disfunction (primary nonfunction)(10 days)
- Liver graft primary disfunction ( Initial Poor Function)(7 days)
- Lenght of ICU Stay(28 days)
- Incidence of Arrythmia requiring clinical treatment(7 days)
- Surgical site infection(28 days)
研究者
Rodolpho Augusto de Moura Pedro
Principal investigator
University of Sao Paulo General Hospital
研究点 (2)
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