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临床试验/NCT01472588
NCT01472588已完成2 期

Translating the DPP Lifestyle Intervention to Rural African-American Communities

University of Arkansas2 个研究点 分布在 1 个国家目标入组 277 人开始时间: 2007年9月最近更新:
适应症

试验速览

阶段
2 期
状态
已完成
入组人数
277
试验地点
2
主要终点
Weight Loss

研究概览

简要总结

Obesity is a significant and growing problem in the US that negatively impacts health and well-being of racial and ethnic minorities, people of low socioeconomic status, and persons living in rural communities and in the South. Obesity is a major concern in Arkansas, where the obesity rate for adults is higher than the rate for other adults in the nation. However effective weight loss programs are not typically available in these communities. Research has shown that the Diabetes Prevention Program (DPP) lifestyle intervention is effective in promoting weight loss in high risk individuals through changes in diet and physical activity that significantly reduce the chances of type 2 diabetes. Effective methods are desperately needed to translate the DPP to community settings, where obesity is a compelling public health burden. A major step in translating the DPP is to examine the efficacy of health professionals and community health workers (CHWs) in delivering the program in real-world settings. This is an important issue from the perspective of how evidence-based weight loss interventions can be provided to underserved, and resource constrained communities that typically may not have access to trained professionals for program delivery. The current project is a 5 year randomized controlled trial that examines DPP delivery and weight outcomes for individuals randomly assigned to either: (1) the DPP intervention delivered by CHWs or (2) the DPP intervention delivered by health professionals or (3) the Self Help condition. The study population consists of overweight adults (body mass index (BMI) > 25) who reside in communities with a high proportion of African Americans. Primary outcome is change in body weight at 16 months. Cost effectiveness and lifestyle behaviors are also evaluated.

研究设计

研究类型
Interventional
分配方式
Randomized
干预模型
Parallel
主要目的
Prevention
盲法
None

入排标准

年龄范围
18 Years 至 —(Adult, Older Adult)
性别
All
接受健康志愿者

入选标准

  • Non-institutionalized men and women aged 18 and older
  • BMI [weight (kg)/ height (m2)] > 25
  • Able to walk for exercise
  • Able to provide informed consent
  • Willing to accept random assignment

排除标准

  • Currently pregnant or nursing, or pregnant within previous 6 months
  • Recent heart attack or stroke (in past 6 months)
  • Congestive heart failure (NYHA Class 3-4)
  • History of bariatric surgery or weight loss in excess of 10% in past 6 months
  • Current use of weight loss medications
  • Another member of household enrolled in study
  • Presence of significant impairment that might interfere with participation, such as underlying disease likely to limit lifespan, infectious disease (e.g., HIV, tuberculosis), substantial cognitive impairment, renal dialysis, diagnosis of schizophrenia, psychosis or substance abuse, or other condition that might compromise participation or for which weight loss is not recommended
  • Plans to move from the area within the study period

结局指标

主要结局

Weight Loss

时间窗: 16 months

change in weight (% loss) from baseline to 16 months

次要结局

  • Physical Activity(16 months)

研究者

申办方类型
Other
责任方
Sponsor

研究点 (2)

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