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临床试验/NCT05567042
NCT05567042尚未招募不适用

A Clinical Study of Epilepsy Localization and Prognosis Based on Positron Emission Tomography and Resting-state Functional Magnetic Resonance Imaging

Li Shuangshuang0 个研究点目标入组 50 人开始时间: 2022年10月最近更新:
适应症

试验速览

阶段
不适用
状态
尚未招募
发起方
入组人数
50
主要终点
Seizure frequency

研究概览

简要总结

  1. By following up the prognosis of surgical patients, the application value of Cortex ID quantitative analysis in the localization of epilepsy foci was studied.
  2. By studying the correlation between autonomic nerve function and epilepsy neural network in epilepsy patients, and analyzing the differences between different epilepsy patients, it can provide more information for judging the prognosis of epilepsy patients.

详细描述

This study included diagnostic trials and case-control studies, which were observational studies with no intervention. First, the demographic and clinical information of epilepsy patients in the Neurology Department of Xijing Hospital were collected, including gender, age, age of onset, course of epilepsy, seizure performance before treatment, seizure frequency before treatment, type and dose of antiepileptic drugs, past history, Family history, etc., as well as imaging, EEG, quality of life, and neuropsychological assessment, etc. were collected; secondly, functional magnetic resonance imaging (fMRI) and 24-hour Holter monitoring were performed on patients who met the inclusion criteria. Positron Emission Computed Tomography (PET) images of patients who have undergone or plan to undergo surgery are analyzed; finally, appropriate statistical methods are used for analysis.

研究设计

研究类型
Observational
观察模型
Cohort
时间视角
Prospective

入排标准

性别
All
接受健康志愿者

入选标准

  • Meet the diagnostic criteria for epilepsy,
  • No contraindications for fMRI examination.
  • The patient had no other heart and lung diseases except epilepsy.
  • Patients and their families were aware of this study and signed informed consent.

排除标准

  • Patients with severe infection, cerebrovascular disease, malignant tumor and other systemic diseases that can affect the nervous system, and those with serious dysfunction of the heart, liver, kidney and other organs.
  • Non-epileptic seizures such as syncope and hysteria.
  • Pregnant or lactating women. Incomplete clinical data

结局指标

主要结局

Seizure frequency

时间窗: 2022-2024

Seizure duration

时间窗: 2022-2024

次要结局

未报告次要终点

研究者

发起方
Li Shuangshuang
申办方类型
Other
责任方
Sponsor Investigator
主要研究者

Li Shuangshuang

Principal Investigator

Xijing Hospital

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