跳至主要内容
临床试验/NCT06059040
NCT06059040尚未招募不适用

Effect of Eliminating Routine Gastric Residual Volume Monitoring on Ventilator-associated Events in Patients Receiving Enteral Feeding

Damanhour University0 个研究点目标入组 160 人开始时间: 2023年10月1日最近更新:
适应症

试验速览

阶段
不适用
状态
尚未招募
入组人数
160
主要终点
eliminating gastric residual volume monitoring on ventilator associated events

研究概览

简要总结

The aims of this study are to investigate the effect of eliminating routine GRV monitoring on VAEs in patients receiving MV and early EF, Determine the effect of eliminating routine GRV monitoring on nutritional adequacy in patients receiving MV and early EF and evaluate the effect of eliminating routine GRV monitoring on feeding intolerance in patients receiving enteral feeding.

详细描述

Early enteral nutrition (EN) is consistently recommended as first line nutrition therapy in critically ill patients since it favorably alters outcome, providing both nutrition and non-nutrition benefits. However, critically ill patients receiving mechanical ventilation (MV) are at risk for regurgitation, pulmonary aspiration, and eventually ventilator-associated pneumonia (VAP). EN may increase these risks when gastrointestinal (GI) dysfunction is present. Gastric residual volume (GRV) is considered a surrogate parameter of GI dysfunction during the progression of enteral feeding in the early phase of critical illness and beyond. About 62% of critically ill patients receive enteral nutrition (EN) and in patients on MV, enteral feeding was connected to a threefold increase in the development of VAP.

A new surveillance definition of ventilator-associated events (VAE) was introduced by the National Healthcare Safety Network (NHSN) in 2013 to identify patients who develop complications of MV. It outlines the various events in a step-by-step fashion, beginning with ventilator-associated complications (VAC), moving on to infectious complications (IVAC), and finally VAP. According to the NHSN, VAEs occur within 9% to 40% of mechanically ventilated patients

研究设计

研究类型
Interventional
分配方式
Randomized
干预模型
Parallel
主要目的
Basic Science
盲法
None

入排标准

年龄范围
18 Years 至 60 Years(Adult)
性别
All
接受健康志愿者

入选标准

  • Adults (aged≥18 years)
  • Newly admitted mechanically ventilated patients who are attached to a mechanical ventilator for at least 48 hours.
  • Starting enteral nutrition via a nasogastric tube within 36 hours after intubation.

排除标准

  • Abdominal surgery within the past month.
  • History of esophageal, duodenal, pancreatic, or gastric surgery.
  • Bleeding from the esophagus, stomach, or bowel.
  • Enteral nutrition via a jejunostomy or gastrostomy.
  • Pregnancy

结局指标

主要结局

eliminating gastric residual volume monitoring on ventilator associated events

时间窗: 3 month

use centers for disease control and prevention (CDC) calculators for evaluating VAE version 9.0 2021

次要结局

  • eliminating gastric residual volume monitoring on nutritional adequacy(3 month)
  • eliminating gastric residual volume monitoring on incidence of feeding intolerance indicators(3 month)

研究者

申办方类型
Other
责任方
Sponsor

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