Effect of Eliminating Gastric Residual Volume Monitoring on Ventilator Associated Events

Not Applicable

Not yet recruiting

• Conditions: Ventilator Associated Pneumonia
• Interventions: Procedure: eliminating gastric residual volume monitoring

• Registration Number: NCT06059040
• Lead Sponsor: Damanhour University

Brief Summary

The aims of this study are to investigate the effect of eliminating routine GRV monitoring on VAEs in patients receiving MV and early EF, Determine the effect of eliminating routine GRV monitoring on nutritional adequacy in patients receiving MV and early EF and evaluate the effect of eliminating routine GRV monitoring on feeding intolerance in patients receiving enteral feeding.

Detailed Description

Early enteral nutrition (EN) is consistently recommended as first line nutrition therapy in critically ill patients since it favorably alters outcome, providing both nutrition and non-nutrition benefits. However, critically ill patients receiving mechanical ventilation (MV) are at risk for regurgitation, pulmonary aspiration, and eventually ventilator-associated pneumonia (VAP). EN may increase these risks when gastrointestinal (GI) dysfunction is present. Gastric residual volume (GRV) is considered a surrogate parameter of GI dysfunction during the progression of enteral feeding in the early phase of critical illness and beyond. About 62% of critically ill patients receive enteral nutrition (EN) and in patients on MV, enteral feeding was connected to a threefold increase in the development of VAP.

A new surveillance definition of ventilator-associated events (VAE) was introduced by the National Healthcare Safety Network (NHSN) in 2013 to identify patients who develop complications of MV. It outlines the various events in a step-by-step fashion, beginning with ventilator-associated complications (VAC), moving on to infectious complications (IVAC), and finally VAP. According to the NHSN, VAEs occur within 9% to 40% of mechanically ventilated patients

Study Timeline

• Status Verified: 2023-08
• Study First Submitted: 2023-09-20
• Study First Submitted QC: 2023-09-26
• Last Update Submitted: 2023-09-26
• Study First Posted: 2023-09-28
• Last Update Posted: 2023-09-28
• Study Start: 2023-10-01
• Primary Completion: 2023-11-01
• Study Completion: 2024-01-01

Recruitment & Eligibility

• Status: NOT_YET_RECRUITING
• Sex: All
• Target Recruitment: 160

Inclusion Criteria

• Adults (aged≥18 years)
• Newly admitted mechanically ventilated patients who are attached to a mechanical ventilator for at least 48 hours.
• Starting enteral nutrition via a nasogastric tube within 36 hours after intubation.

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Exclusion Criteria

• Abdominal surgery within the past month.
• History of esophageal, duodenal, pancreatic, or gastric surgery.
• Bleeding from the esophagus, stomach, or bowel.
• Enteral nutrition via a jejunostomy or gastrostomy.
• Pregnancy

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Study & Design

• Study Type: INTERVENTIONAL
• Study Design: PARALLEL

Arm && Interventions

Group	Intervention	Description
intervention groups	eliminating gastric residual volume monitoring	Patients in the intervention group will not be monitored for GRV (no GRV monitoring) and will be evaluated for the presence of feeding intolerance indicators such as vomiting, regurgitation, and abdominal distention.

Primary Outcome Measures

Name	Time	Method
eliminating gastric residual volume monitoring on ventilator associated events	3 month	use centers for disease control and prevention (CDC) calculators for evaluating VAE version 9.0 2021

Secondary Outcome Measures

Name	Time	Method
eliminating gastric residual volume monitoring on nutritional adequacy	3 month	evaluation daily caloric requirement by body mass index that calculated using the equation (Weight in kg /height in cm) 2
eliminating gastric residual volume monitoring on incidence of feeding intolerance indicators	3 month	evaluation of abdominal circumference, abdominal distension, bowel sounds, the episodes of vomiting and diarrhea