Coenzyme Q10 as an Adjunct Therapy in Pediatric Community-Acquired Pneumonia
试验速览
- 阶段
- 不适用
- 状态
- 尚未招募
- 入组人数
- 120
- 试验地点
- 1
- 主要终点
- Normalization of respiratory rate
研究概览
简要总结
The aim of this work is to assess the benefit of coenzyme Q10 supplementation, in addition to standard antibiotic and other supportive therapy, in the management of hospitalized children with community acquired pneumonia
研究设计
- 研究类型
- Interventional
- 分配方式
- Randomized
- 干预模型
- Parallel
- 主要目的
- Treatment
- 盲法
- None
入排标准
- 年龄范围
- 2 Months 至 18 Years（Child, Adult）
- 性别
- All
- 接受健康志愿者
- 否
入选标准
- •All children aged 2 months -18 years with community acquired pneumonia diagnosed by signs and symptoms of CAP including; chest pain, dyspnea, tachypnea, or abnormal auscultatory findings plus focal findings on chest x ray indicating community acquired pneumonia
排除标准
- •Children with immunodeficiency, chronic lung disease, malignancy, congenital lung anomalies, underlying disorder impacting respiration i.e. genetic, metabolic, neuromuscular disorders, children with CHD affecting the pulmonary blood flow.
研究组 & 干预措施
60 children with community acquired pneumonia will receive oral coenzymeQ10
干预措施: oral coenzymeQ10 (Drug)
结局指标
主要结局
Normalization of respiratory rate
时间窗: 3 days
Normalization of oxygen saturation
时间窗: 3 days
Serum C-Reactive Protein (CRP) Level
时间窗: 5 days
Blood samples will be collected, and CRP concentration will be expressed in milligrams per liter (mg/L).
Normalization of temperature
时间窗: 3 days
Normalization of Feeding Behavior Assessed by Oral Intake Tolerance
时间窗: 3 days
Normalization of feeding refusal will be assessed by evaluating the child's ability to tolerate age-appropriate oral feeding without refusal over a 3-day observation period.
Serum Lactate Dehydrogenase (LDH) Level
时间窗: 5 days
LDH concentration will be reported in units per liter (U/L) from venous blood samples.
Prognostic Nutritional Index
时间窗: 5 days
Systemic Immune-Inflammation Index
时间窗: 5 days
Serum C-Reactive Protein to Albumin Ratio (CRP/Albumin Ratio)
时间窗: 5 days
The serum C-reactive protein to albumin ratio (CRP/albumin ratio) will be calculated as a single composite outcome measure using laboratory values obtained from the same blood sample.
Time of clinical stability
时间窗: 3-5 days
次要结局
- Length of hospital stay(10-21 days)
- Number of Participants Requiring Surgical Intervention(21-30 days)
研究者
Rehab Zaki Elmeazawy
Lecturer of pediatrics
Tanta University