Post-Market BTVA Registry

Recruiting

• Conditions: Emphysema or COPD
• Interventions: Device: Bronchoscopic Thermal Vapor Ablation

• Registration Number: NCT03318406
• Lead Sponsor: Uptake Medical Technology, Inc.

Brief Summary

Bronchoscopic thermal vapor ablation using Uptake Medical Technology Inc.'s InterVapor System is indicated for treatment of patients with heterogeneous upper lobe emphysema. This study is a retrospective and prospective, observational, multi-center, post-market registry of patients prescribed InterVapor. The primary objective of the Registry is to describe the long-term impact of InterVapor treatment on patient quality of life (QOL) in a real-world setting. After InterVapor treatment, patients will be followed for 5 years as per the standard of care and safety and efficacy data (quality of life, pulmonary function, exercise capacity) collected as part of the registry.

Detailed Description

The BTVA Registry will enroll up to 300 patients with upper lobe predominant emphysema that are being treated with BTVA at sites located in the EU and other select geographies. Patients will be followed as per standard of care and the registry will collect follow-up data for five years following treatment. The follow up data collected will include pulmonary function measurements (spirometry, body plethysmography, and diffusing capacity for carbon monoxide), exercise capacity (six minute walk test), imaging findings (chest x-ray and CT), and a quality of life questionnaire (SGRQ-C). All serious and non-serious adverse events will also be collected for the duration of the study in order to assess safety. Serious adverse events will be adjudicated by an independent medical monitor in order to establish relatedness to the InterVapor device and procedure.

Descriptive statistics will be used to summarize all safety and effectiveness data. There is no predefined hypothesis regarding the magnitude of effectiveness of InterVapor or the incidence of specific safety outcomes.

Monitoring of the registry study will be undertaken as a continuous process to ensure that high-quality data are obtained and to ensure compliance with registry procedures.

Study Timeline

• Study First Submitted: 2017-10-13
• Study First Submitted QC: 2017-10-18
• Study First Posted: 2017-10-23
• Study Start: 2018-03-22
• Status Verified: 2025-01
• Last Update Submitted: 2025-01-25
• Last Update Posted: 2025-01-28
• Primary Completion: 2027-12-01
• Study Completion: 2030-12-01

Recruitment & Eligibility

• Status: RECRUITING
• Sex: All
• Target Recruitment: 300

Inclusion Criteria

1. Patients will have heterogeneous emphysema, as evidenced by high-resolution computed tomography (HRCT) demonstrating a heterogeneity index > or equal to 1.2 in at least one segment to be treated
2. Patients must be > or equal to 18 years of age
3. Patients are required to provide informed consent prior to inclusion in the Registry

Exclusion Criteria

1. FEV1 < 20% predicted

2. DLCO < 20% predicted

3. Inability to walk > 140 meters in 6 minutes (6MWD) following optimized medical management

4. Unstable COPD (any of the following):

   1. > 3 COPD related hospitalizations requiring antibiotics in past 12 months
   2. COPD related hospitalization in past 3 months
   3. daily use of systemic steroids, i.e. > 5 mg prednisolone

5. Concomitant illnesses or medications that would pose a significant increased risk for complications following treatment with InterVapor. Examples of particular relevance include: immune system disorders, immunosuppressant medications of clinical relevance, bleeding disorders and unstable cardiovascular conditions, history of asthma or alpha-1 antitrypsin deficiency

6. Newly prescribed morphine derivatives within the last 4 weeks

7. Pregnant or breastfeeding

8. Highly diseased lower lobes (tissue to air ratio of <11%)

9. Bacterial infection or symptoms indicative of active infection (i.e., fever, elevated white blood cell count)

10. Presence of single large bulla (defined as > 1/3 volume of lobe) or a paraseptal distribution of emphysema in the treated lobe

11. Recent respiratory infections or COPD exacerbation in preceding 6 weeks -

Study & Design

• Study Type: OBSERVATIONAL
• Study Design: Not specified

Arm && Interventions

Group	Intervention	Description
BTVA treated patients	Bronchoscopic Thermal Vapor Ablation	Patients with heterogeneous upper lobe emphysema undergoing Bronchoscopic Thermal Vapor Ablation treatment

Primary Outcome Measures

Name	Time	Method
Change in Quality of Life	Baseline to 24 months	Change in Quality of Life score as assessed by the SGRQ-C questionnaire

Secondary Outcome Measures

Name	Time	Method
Change in FEV1	Baseline to 12 months	Change in Forced Expired Volume in 1 second
Exercise Tolerance	Baseline to 12 months	Change in six minute walk distance
Change in RV	Baseline to 12 months	Change in Residual Volume
Change in FVC	Baseline to 12 months	Change in Forced Vital Capacity
Change in TLC	Baseline to 12 months	Change in Total Lung Capacity
Serious Adverse Events	6 and 12 months	procedure and device related serious adverse events, major medical complications
Change in DLCO	Baseline to 12 months	Change in Diffusing capacity of the lung for carbon monoxide
Lung volume reduction	Baseline to 6 months	change in lung volume assessed by CT

Trial Locations

Locations (20)

Krankenhaus Nord - Klinik Floridsdorf; 🇦🇹 Vienna, Austria

Sozialstiftung Bamberg, Klinikum am Bruderwald; 🇩🇪 Bamberg, Germany

DRK Kliniken Berlin / Mitte; 🇩🇪 Berlin, Germany

FORSCHUNGSINSTITUT Havelhöhe gGmbH; 🇩🇪 Berlin, Germany

Ruhrlandklinik - Westdeutsches Lungenzentrum am Universitätsklinikum Essen gGmbH; 🇩🇪 Essen, Germany

Asklepios Fachkliniken München-Gauting; 🇩🇪 Gauting, Germany

Martin-Luther-Universität Halle-Wittenberg (Saale); 🇩🇪 Halle, Germany

Thoraxklinik Heidelberg; 🇩🇪 Heidelberg, Germany

Lungenklinik Hemer; 🇩🇪 Hemer, Germany

Lungenfachklinik Immenhausen; 🇩🇪 Immenhausen, Germany

Krankenhaus Martha-Maria München; 🇩🇪 München, Germany

Klinikum Nürnberg Nord; 🇩🇪 Nürnberg, Germany

Krankenhaus vom Roten Kreuz Bad Cannstatt GmbH; 🇩🇪 Stuttgart, Germany

Klinik Schillerhöhe; 🇩🇪 Stuttgart, Germany

Kantonsspital Aarau AG; 🇨🇭 Aarau, Switzerland

University Hospital Basel; 🇨🇭 Basel, Switzerland

Lungen-und Schlafzentrum am Lindenhofspital AG, Bern; 🇨🇭 Bern, Switzerland

Kantonsspital St.Gallen; 🇨🇭 St. Gallen, Switzerland

LungenZentrum Hirslanden; 🇨🇭 Zürich, Switzerland

Universitäts Spital Zürich; 🇨🇭 Zürich, Switzerland