Operant H-reflex Down-conditioning of Rectus Femoris in Post-stroke Stiff Knee Gait
试验速览
- 阶段
- 早期 1 期
- 状态
- 已完成
- 入组人数
- 7
- 试验地点
- 2
- 主要终点
- Percentage Change From Baseline in RF H-reflex Magnitude
研究概览
简要总结
The investigators performed a feasibility trial of operant conditioning of spinal reflex excitability on five healthy individuals and two post-stroke individuals. The investigators found that operant conditioning of rectus femoris reflex excitability was feasible in all participants.
详细描述
The investigators performed a cohort study on 7 individuals (5 healthy, 2 post-stroke) to examine the feasibility of operant down-conditioning of rectus femoris reflex excitability (i.e. H-reflex). Each individual performed 30 sessions, 6 baseline sessions with no operant conditioning (225 trials of surface electrical stimulation of the femoral nerve), followed by 24 training sessions (20 baseline trials followed by 225 trials with feedback of H-reflex magnitude). The investigators' main outcome measure was rectus femoris H-reflex magnitude. We also examined H-reflex magnitude of other quadriceps muscles.
研究设计
- 研究类型
- Interventional
- 分配方式
- Na
- 干预模型
- Single Group
- 主要目的
- Treatment
- 盲法
- None
入排标准
- 年龄范围
- 18 Years 至 75 Years（Adult, Older Adult）
- 性别
- All
- 接受健康志愿者
- 是
入选标准
- •Premorbidly independent
- •Mild to moderate impairment determined by standard practices per the physical therapist
- •Ability to stand for 10-minute intervals unassisted
- •Ability to walk for 10-minutes on a treadmill
- •Reduced knee flexion during phase and SKG as determined by a clinician
- •Hemiparesis
- •Ability to provide informed consent
排除标准
- •History of cerebellar stroke, multiple stroke
- •History of serious lower limb musculoskeletal injury
- •Functionally relevant osteoarthritis and weight-bearing restrictions
- •Have condition related to claustrophobia or other MRI contraindications
- •Functionally relevant cognitive impairment
- •Functionally relevant vision impairment
- •Took antispasmodic medication one day prior to the session
- •Had Botox injection one week prior to the session
- •Pregnant women
结局指标
主要结局
Percentage Change From Baseline in RF H-reflex Magnitude
时间窗: 3 months
H-reflex magnitude of rectus femoris. Lower values are considered better. The H-reflex is the amplitude of the monosynaptic spinal reflex, elicitied by electrical stimulation of the femoral nerve, normalized by the preceding M-wave. The M-wave is the amplitude of the muscle activity response to surface electrical stimulation of the femoral nerve. All muscle activity measured at the individual's rectus femoris of the stimulated limb. A value of 100% would mean no change in reflex magnitude, whereas a change of -20%, for instance, would mean a 20% drop in reflex magnitude over the 3 month training period.
次要结局
- Percentage Change From Baseline in VM H-reflex Magnitude(3 months)