Blink reflex changes after GON-injection in cluster headache: Clinical and pathophysiological implications.

Recruiting

Conditions: Hortons neuralgia
Suicide headache
10019231

Registration Number: NL-OMON49065

Lead Sponsor: eids Universitair Medisch Centrum

Brief Summary: Not available

Detailed Description: Not available

Recruitment & Eligibility

Status: Recruiting

Sex: Not specified

Target Recruitment: 40

Inclusion Criteria

- Patients have to be diagnosed with episodic or chronic cluster headache
according to the international classification of headache disorders * third
edition, ICHD-3
- Patients have to be aged 18-75 years
- Patients should be receiving a GON-injection as regular therapy for episodic
or chronic cluster headache

Exclusion Criteria

Treatment with a SPG-stimulator or an occipital nerve stimulator

Study & Design

Study Type: Observational non invasive

Study Design: Not specified

Primary Outcome Measures

Name	Time	Method
<p>The primary endpoint of this study is the difference in mean ipsilateral R2<br /><br>latency of the blink reflex between the one-week and baseline timepoint.</p><br>

Secondary Outcome Measures

Name	Time	Method
<p>* Clinical response to GON-injection as measured by daily attack frequency,<br /><br>attack intensity and duration<br /><br>* The association between the mean ipsi- and contralateral R2 latency of the<br /><br>blink reflex and the clinical response, as measured in percentage change in<br /><br>attack frequency, to the GON-injection<br /><br>* The association between the mean ipsi- and contralateral AUC of the blink<br /><br>reflex and the clinical response to the GON-injection<br /><br>* The change in ipsi- and contralateral mean R2 latency and mean AUC between<br /><br>all 4 time points<br /><br>* The difference in mean trigeminal sensible and pain threshold between all 4<br /><br>time-points<br /><br>* The association between trigeminal sensible and pain threshold and clinical<br /><br>response to the GON-injection</p><br>