Enhancing the clinical effectiveness of deep TMS treatment of depressio

Not Applicable

Recruiting

• Conditions: Major Depressive Disorder; Mental Health - Depression

• Registration Number: ACTRN12622001345774
• Lead Sponsor: Australian National University

Brief Summary

Not available

Detailed Description

Not available

Study Timeline

• Results First Posted: 1900-01-01
• Study Start: 2022-10-19
• Last Update Posted: 1 April 2024

Recruitment & Eligibility

• Status: Recruiting
• Sex: All
• Target Recruitment: 240

Inclusion Criteria

Diagnosis of major depressive episode (MDE), in accordance with the Diagnostic and Statistical Manual of Mental Disorders 5th edition (DSM-5), in the context of unipolar major depressive disorder or bipolar affective disorder.
- 18-85 years of age.
- Treatment resistant depression at Stage II of the Thase and Rush classification.
- Hamilton Depression Rating Scale (HAMD) score of >17 (moderate – severe depression).
- No increase or initiation of new antidepressant therapy in the four weeks prior to screening.
- Demonstrated capacity to give informed consent.

Exclusion Criteria

- Inability to provide informed consent
- Medically unstable patients
- Concomitant neurological disorder or a history of a seizure disorder.
- Patients who are pregnant or breastfeeding.
- Active suicidal intent
- Any psychotic disorder or current active psychotic symptoms
-Patients who have intracranial implants deemed unsafe for TMS.
- Significant difficulties understanding or communicating in English

Study & Design

• Study Type: Interventional
• Study Design: Not specified