A Phase I Study of Concomitant Chemoradiotherapy With Weekly Paclitaxel and Vinorelbine With Filgrastim Granulocyte Colony Stimulating Factor (GCSF) Support in Patients With Advanced Breast Cancer

University of Chicago1 site in 1 country26 target enrollmentJune 1999

ConditionsBreast Cancer

DrugsPaclitaxel Vinorelbine Filgrastim

Overview

Phase: Phase 1
Intervention: Not specified
Conditions: Breast Cancer
Sponsor: University of Chicago
Enrollment: 26
Locations: 1
Primary Endpoint: dose-limiting toxicity
Status: Completed
Last Updated: 12 years ago

Overview Investigators Eligibility Criteria Outcomes Sites Similar Trials

Overview

Brief Summary

The goal of this study is to determine the feasibility based on toxicity and response rate of giving paclitaxel weekly with concomitant every-other week radiotherapy to limit skin toxicity. This study will also seek to determine the maximally tolerated dose of Navelbine added to this combination when followed by Filgrastim and the dose-limiting toxicities of this regimen.

Registry

clinicaltrials.gov

Start Date

June 1999

End Date

November 2012

Last Updated

12 years ago

Study Type

Interventional

Study Design

Single Group

Sex

All

Investigators

Sponsor

University of Chicago

Responsible Party

Sponsor

Eligibility Criteria

Inclusion Criteria

•Histologically or cytologically confirmed adenocarcinoma of the male or female breast (male or female) with gross, uncontrolled, unresectable breast and/or chest wall disease including:
•patients with locally advanced unresectable stage IIIa or IIIb;
•patients with locally recurrent (including locoregional lymph nodes) disease for which curative surgery is not thought possible
•patients with metastatic disease AND uncontrolled locoregional disease are eligible.
•Prior chemotherapy allowed, except for nitrosoureas and mitomycin chemotherapy or high dose chemotherapy with marrow or stem cell rescue.
•Prior palliative radiation to sites of metastases allowed (i.e. bone, brain, lung)
•4 weeks since any prior treatments (excluding hormonal therapy). Concurrent hormonal therapy is not allowed.
•Aged 18 years or older
•CALGB performance status of 0 - 2
•Life expectance of at least 12 weeks

Exclusion Criteria

•Prior breast or chest wall radiation is not allowed unless the proposed site radiation port does not overlap with prior ports
•Subjects must not be pregnant (females able to have children must have negative pregnancy test and agree to use adequate contraception)
•Patients with a documented hypersensitivity to E.coli derived proteins are excluded.
•No other serious medical condition such as uncontrolled infection that in the opinion of the investigators places patient at undue risk for study treatment