Effect of Hydrogen-rich Water Supplementation During Tapering on Recovery After Functional Overreaching in Competitive Male Basketball Players: A Randomized, Double-blind, Placebo-controlled Paralel-group Trial
试验速览
- 阶段
- 不适用
- 状态
- 招募中
- 入组人数
- 30
- 试验地点
- 2
- 主要终点
- RMSSD
研究概览
简要总结
The goal of this clinical trial is to evaluate whether hydrogen-rich water supplementation during tapering improves recovery after functional overreaching in competitive male basketball players aged 18-35 years. The main questions it aims to answer are:
- Does hydrogen-rich water improve autonomic recovery after functional overreaching?
- Does hydrogen-rich water improve recovery in biochemical, performance, and subjective feeling outcomes during tapering?
Researchers will compare hydrogen-rich water to placebo (water containing no molecular hydrogen) to determine whether molecular hydrogen improves recovery after accumulated fatigue has been induced by functional overreaching. Participants will:
- Complete a training cycle including normal training, functional overreaching, and tapering.
- Consume hydrogen-rich or placebo water daily during the one-week tapering period.
- Undergo repeated testing of autonomic nervous system, blood biochemical markers, performance, and subjective soreness.
详细描述
The study consists of an initial screening and entry testing phase, followed by one week of normal training, two weeks of functional overreaching, and one week of tapering. During the functional overreaching period, training load is increased to approximately 120-130% of normal training load to induce accumulated fatigue. During the tapering period, training volume is reduced to approximately 50-60% of normal training volume to support recovery and performance rebound.
The molecular hydrogen is administered only during the tapering period. Participants in the experimental group consume 2.5 L per day of hydrogen-rich water. The total daily dose is divided into 0.5 L in the morning, 1.5 L around training, and 0.5 L in the evening. Participants in the placebo group consume visually matched placebo water according to the same total daily intake and timing schedule. Supplementation adherence is monitored using logs, dose counts, and attendance records. Participants are randomly assigned in a 1:1 ratio to either the experimental group or the placebo group. Randomization is performed using a block scheme and a computer random number generator.
Testing is performed at multiple time points: entry laboratory testing, baseline after normal training, post-functional overreaching, and post-taper. The primary interval for evaluation is the change from post-functional overreaching to post-taper. Statistical analysis is based on a t-test or analysis of variance. Data that not follow a normal distribution are treated using a logarithmic transformation or analyzed using nonparametric tests. The significance level is set at 0.05.
研究设计
- 研究类型
- Interventional
- 分配方式
- Randomized
- 干预模型
- Parallel
- 主要目的
- Basic Science
- 盲法
- Double (Participant, Investigator)
入排标准
- 年龄范围
- 18 Years 至 35 Years（Adult）
- 性别
- Male
- 接受健康志愿者
- 是
入选标准
- •Competitive male basketball players.
- •Signed informed consent.
- •Completion of entry medical and laboratory screening.
排除标准
- •Acute injury or infection.
- •History or presence of relevant cardiovascular, respiratory, metabolic, or other disease that may affect the study results.
- •Use of medication affecting recovery markers or study results.
研究组 & 干预措施
Hydrogen-rich water
Hydrogen-rich water administered at a dose of 2.5 L per day during a one-week tapering period.
干预措施: Hydrogen-rich water (Dietary Supplement)
Placebo water
Placebo water administered at a dose of 2.5 L per day during a one-week tapering period.
干预措施: Placebo water (Dietary Supplement)
结局指标
主要结局
RMSSD
时间窗: One-week change between post-overreaching and post-taper.
The root mean square of successive differences of RR intervals (RMSSD) is used as an index of parasympathetic activity and is calculated from an ECG using heart rate variability analysis.
次要结局
- Creatine kinase(One-week change between post-overreaching and post-taper.)
- High-sensitivity C-reactive protein(One-week change between post-overreaching and post-taper.)
- Cortisol(One-week change between post-overreaching and post-taper.)
- Testosterone(One-week change between post-overreaching and post-taper.)
- Urea(One-week change between post-overreaching and post-taper.)
- Leukocytes(One-week change between post-overreaching and post-taper.)
- Lymphocytes(One-week change between post-overreaching and post-taper.)
- Neutrophils(One-week change between post-overreaching and post-taper.)
- Reactive strength index(One-week change between post-overreaching and post-taper.)
- Hangrip test(One-week change between post-overreaching and post-taper.)
- 20-m sprint(One-week change between post-overreaching and post-taper.)
- Repeated sprint(One-week change between post-overreaching and post-taper.)
- Agility T-test(One-week change between post-overreaching and post-taper.)
- Basketball jump shot accuracy test(One-week change between post-overreaching and post-taper.)
- Muscle soreness(One-week change between post-overreaching and post-taper.)
研究者
Jakub Krejci
Assistant professor
Palacky University