REMIC TOXIN: Utility in REnal disease of Measuring Indoxyl sulphate and p-Cresyl sulphate To predict OXidative stress, Inflammation and cliNical outcomes

Not Applicable

Completed

• Conditions: Chronic Kidney Disease; Cardiovascular disease; Renal and Urogenital - Kidney disease; Cardiovascular - Coronary heart disease

• Registration Number: ACTRN12612000760875
• Lead Sponsor: Princess Alexandra Hospital

Brief Summary

Not available

Detailed Description

Not available

Study Timeline

• Results First Posted: 1900-01-01
• Study Start: 2012-07-17
• Last Update Posted: 13 January 2020

Recruitment & Eligibility

• Status: Completed
• Sex: All
• Target Recruitment: 300

Inclusion Criteria

Chronic Kidney Disease (CKD) (stage1-5D)
>/= 18 years
Able to provide informed consent

Exclusion Criteria

Non CKD
Unable/unwilling to give informed consent
Unable/unwilling to comply with frequent follow-up
Life expectancy was severely limited due to pre-existing malignancy or other disease (<6 months)
Pregnancy

Study & Design

• Study Type: Observational
• Study Design: Not specified

Primary Outcome Measures

Name	Time	Method
Indoxyl sulphate concentration (mg/L) (serum analysis)[baseline, year 1, year 2];P-cresyl sulphate concentration (mg/L) (serum analysis)[baseline, year 1, year 2]

Secondary Outcome Measures

Name	Time	Method
Cardiovascular risk factors- arterial stiffness by aortic pulse-wave velocity (PWV); atheroma burden by carotid intima-media thickness (cIMT) and endothelial function by flow-mediated dilation (FMD) of the brachial artery.[baseline, year 1, year 2];Mortality- all cause and cardiovascular (death registry)[study duration ie. 0-2 years];Kidney Function- serum creatinine (serum analysis), urinary protein (mid stream urinary analysis)[baseline, year 1, year 2];Inflammation- C-Reactive Protein, Interleukin-6 (serum analysis)[baseline, year 1, year 2]