Comparison,Formulation,Characterisation and Clinical effectiveness of nanogel of Acorus calamus and Butea monosperma with Carbamazepine in the treatment of trigeminal neuralgia-A clinical trial

The International Association of Pain defines trigeminal neuralgia as a sudden, unilateral, severe, brief, stabbing, and recurrent pain along the course of the distribution of the trigeminal nerves. Carbamazepine is an anticonvulsant as well as an antiepileptic drug, which is considered a gold standard drug in the treatment of trigeminal neuralgia.ommon side effect of bone marrow suppression, causing agranulocytosis and drowsiness. Agranulocytosis is more dangerous when the total neutrophil count decreases to 100 cells/mm3. Root rhizomes of Acorus calamus has a property such as anticancer properties, antioxidant properties, and neuroprotective properties by inhibiting the action of calcium channels, which the mainly responsible for the pain conduction pathway. By inhibiting the calcium channel inhibitory action, it greatly reduces the pain intensity as well. the flowers of Butea monosperma have neuroprotective properties as well as antioxidant and calcium channel inhibitory action.