Treatment Intensification Based on Disease Activity Parameters or on Cartilage Breakdown Markers in Early Rheumatoid Arthritis.

Completed

• Registration Number: NL-OMON28499

Brief Summary

/A

Detailed Description

Not available

Study Timeline

• Results First Posted: 1900-01-01
• Last Update Posted: 28 February 2024

Recruitment & Eligibility

• Status: Completed
• Sex: Not specified
• Target Recruitment: 40

Inclusion Criteria

Patients must have:

1. Rheumatoid arthritis (ACR criteria met cumulatively);

Exclusion Criteria

1. Unwillingness to participate in the study and comply with its procedures by signing a written informed consent;

Study & Design

• Study Type: Interventional
• Study Design: Not specified

Primary Outcome Measures

Name	Time	Method
1. DAS: Disease activity score (28 joints) calculated from swollen and tender joint counts, ESR, patient global assessment of disease activity (10 cm VAS);<br /><br>2. CTX-2: measured in spot urine (delivered 1 week before visit) together with creatinine (method Garnero, Lyon).

Secondary Outcome Measures

Name	Time	Method
1. WHO/ILAR core set; DAS remission, EULAR improvement; ACR remission, ACR20,etc; EuroQoL;<br /><br>2. Efficacy Self assessment: RADAI joint score, fatigue VAS; <br /><br>3. Bone Mass: DEXA lumbar spine; Right hip (neck).