Gastric Cancer Prevention for Indigenous Peoples
- Conditions
- Gastric Cancer
- Registration Number
- NCT03900910
- Lead Sponsor
- National Taiwan University Hospital
- Brief Summary
The incidence of gastric cancer in local indigenous peoples is higher than the non-Indigenous counterpart in Taiwan. How to design an effective prevention strategy for gastric cancer is of importance. The present study aimed to identify the causes that may account for the health inequalities, allowing generation of a plan of action on the whole population scale.
- Detailed Description
Owing to the continuing gap in cancer burden between Indigenous and non-Indigenous peoples, reducing health disparities has drawn worldwide attention. Evidence indicates that the gastric cancer incidence and mortality rates in Indigenous peoples are much higher than those of non-Indigenous counterparts living in the same areas. Exposure to more risk factors from social habits, lifestyle, and Helicobacter pylori infection has been considered the cause. However, even though gastric cancer has been repeatedly shown to be preventable by eliminating risk factors, eradication policies are rarely designed for Indigenous peoples. Possible obstacles may include the lack of Indigenous health statistics, inadequate access to care, difficulty in modifying social habits and lifestyles, and the presence of environmental and cultural barriers. Developing and implementing a preventive strategy following the evidence-based principle remains a challenge.
In Taiwan, the number of Indigenous peoples has grown; however, their life expectancy remains substantially lower than that of the non-Indigenous population. Cancer is the most prevalent cause of death for Indigenous peoples and a disproportionate prevalence of certain kinds of cancer is noted for Indigenous peoples. These observations provide an opportunity to establish a plan of action, in which a specific intervention is developed to decrease the threat from each specific cancer so that the overall disparate burden can be reduced in a stepwise manner.
Recruitment & Eligibility
- Status
- ENROLLING_BY_INVITATION
- Sex
- All
- Target Recruitment
- 30000
- Aged 20-60 years
- Mentally competent to be able to understand the consent form
- Able to communicate with study staff for individuals
- Pregnancy
- Individuals with major comorbid diseases
Study & Design
- Study Type
- INTERVENTIONAL
- Study Design
- SINGLE_GROUP
- Primary Outcome Measures
Name Time Method Gastric cancer incidence After at least 5 years, the gastric cancer incidence per 100,000 person-years is calculated by the person-years of follow-up. To assess the effect of H. pylori eradication for gastric cancer prevention
Helicobacter eradication rate At least 5 years To assess the eradication rate of anti-H. pylori treatment.
The participation rate Screening program quality indicator The number of participants divided by the number of invitees
The positivity rate Screening program quality indicator The number of positive test results divided by the number of participants
The referral-to-treatment rate Screening program quality indicator The number of individuals who received anti-H pylori treatment divided by the number of positive test results
The reinfection rate Screening program quality indicator The number of positive test results divided by the person-years of follow-up
- Secondary Outcome Measures
Name Time Method
Trial Locations
- Locations (1)
National Taiwan University Hospital
🇨🇳Taipei City, Taiwan
National Taiwan University Hospital🇨🇳Taipei City, Taiwan