Long-term Effects of Cannabis Use on Social and Emotional Brain Processes in Dependent Cannabis Users After a 28 Day Abstinence Period
Overview
- Phase
- Not Applicable
- Intervention
- Not specified
- Conditions
- Cannabis Dependence
- Sponsor
- University of Electronic Science and Technology of China
- Enrollment
- 43
- Locations
- 1
- Primary Endpoint
- fMRI neural activation patterns of social-emotional brain processes after 28 day abstinence
- Status
- Completed
- Last Updated
- 9 years ago
Overview
Brief Summary
The aim of this functional magnetic resonance imaging (fMRI) study is to find out whether and how social and emotional brain function are altered in dependent cannabis users relative to healthy non-using control subjects after a 28 supervised abstinence period. Previous research in cannabis users has predominantly focused on cognitive functions. Moreover, studies have implicated that observed deficits in cannabis users may regenerate after a prolonged abstinence period. Findings might provide important information with respect to relapse vulnerability.
Investigators
Benjamin Becker
Prof. Dr. rer. nat.
University of Electronic Science and Technology of China
Eligibility Criteria
Inclusion Criteria
- •Cannabis dependence according to DSM 4 criteria
- •28 days of supervised abstinence
Exclusion Criteria
- •other DSM 4 diagnosis
- •neurological disorders
Outcomes
Primary Outcomes
fMRI neural activation patterns of social-emotional brain processes after 28 day abstinence
Time Frame: one timepoint = fMRI assessment after 28 day abstinence period
Activity patterns in core regions of the emotion processing \& addiction-related brain networks (e.g. striatal regions, insular cortex, prefrontal cortex) will be assessed after 28-days of abstinence. Alterations will be determined by comparison with matched non-drug using controls
Secondary Outcomes
- Ratings of subjective experience (pleasantness, rewarding value) will be assessed after 28 days of abstinence(one timepoint = during fMRI assessment after 28 day abstinence period)
- Relapse interview assessed with Timeline-Followback Method(one timepoint = 24 months post-fMRI-session)