The use of advanced organ imaging in radiotherapy of the upper-abdomen for kidney response assessment and treatment optimisatio

Not Applicable

Completed

• Conditions: Pancreatic cancer; Stomach cancer; Cancer - Pancreatic; Cancer - Stomach

• Registration Number: ACTRN12609000322235
• Lead Sponsor: Sir Charles Gairdner Hospital

Brief Summary

Not available

Detailed Description

Not available

Study Timeline

• Results First Posted: 1900-01-01
• Study Start: 2009-05-21
• Study Completion: 2018-06-01
• Last Update Posted: 28 June 2021

Recruitment & Eligibility

• Status: Completed
• Sex: All
• Target Recruitment: 35

Inclusion Criteria

Patient has histologically/cytologically proven adenocarcinoma of the pancreas or upper-gastrointestinal (GI) tract. Metastatic disease status excluded on whole body computed tomography (CT) series.
Locoregional staging of primary disease has been undertaken with dual phase (arterial and portal) spiral CT.
Adequate bone marrow function: Haemoglobin (Hb)>10, White Blood Cells (WBC)>3.5 (Neutrophilis>1.5), Platelets >100
Serum creatinine <150
Patient has given written informed consent.
Performance status is East Coast Oncology Group (ECOG) grade 0, 1 or 2

Exclusion Criteria

Major co-morbid illnesses that, in the opinion of the investigator, would jeopardise the likely completion of the treatment program.
Patients with significant loss of bodyweight (>15% weight loss since diagnosis).
Treatment with any previous cytotoxic chemotherapy for the malignancy.
Previous abdominal radiotherapy.

Study & Design

• Study Type: Observational
• Study Design: Not specified

Primary Outcome Measures

Name	Time	Method
Observed change in regional kidney function as indicated by SPECT signal[Baseline, 4 weeks, 12 weeks, 26 weeks, 52 weeks, 78 weeks];Change in glomerular filtration rate (GFR) measured via serum creatinine in blood analysis[Baseline, 4 weeks, 12 weeks, 26 weeks, 52 weeks, 78 weeks]

Secondary Outcome Measures

Name	Time	Method
rea and electrolyte levels assessed via blood analysis[Baseline, 4 weeks, 12 weeks, 26 weeks, 52 weeks, 78 weeks]