Perioperative Hyperglycaemia in Primary Total Hip and Knee Replacement

Completed

• Conditions: Hip Replacement; Knee Replacement; Hyperglycemia

• Registration Number: NCT01021826
• Lead Sponsor: Coxa, Hospital for Joint Replacement

Brief Summary

The purpose of this study is to analyze how common stress hyperglycaemia (abnormally high blood glucose) is in primary hip and knee replacement surgeries and which factors predispose to hyperglycaemia.

Detailed Description

Postoperative infections remain one of the most frequent reasons of failure of hip and knee prostheses. Diabetes increases the risk of infections. In other fields of surgery, hyperglycemia induced by surgical stress (stress/perioperative hyperglycemia) has been associated with higher rates of postoperative infections and complications. Such studies have not yet been performed in the field of joint replacement surgery. Unlike several other risk factors of infected joint replacements, hyperglycemia is potentially modifiable and therefore its prevalence, predisposing factors and association with postoperative infections are of interest.

Study Timeline

• Study First Submitted: 2009-11-27
• Study First Submitted QC: 2009-11-27
• Study First Posted: 2009-11-30
• Study Start: 2009-12
• Primary Completion: 2011-07
• Study Completion: 2012-09
• Status Verified: 2015-08
• Last Update Submitted: 2015-08-09
• Last Update Posted: 2015-08-11

Recruitment & Eligibility

• Status: COMPLETED
• Sex: All
• Target Recruitment: 193

Inclusion Criteria

• Diagnosis of osteoarthritis
• Scheduled for primary hip or knee replacement

Exclusion Criteria

• Arthritis other than osteoarthritis
• Medication affecting glucose metabolism (excl. antidiabetic agents)
• Not undergoing hip or knee replacement

Study & Design

• Study Type: OBSERVATIONAL
• Study Design: Not specified

Primary Outcome Measures

Name	Time	Method
Occurrence (and severity) of hyperglycemia following primary hip or knee replacement	3 days (average)	Follow-up covers postoperative hospital stay at the operating hospital, that lasts typically 2-5 days.

Secondary Outcome Measures

Name	Time	Method
Incidence of surgical-site infections	1 year
Prevalence of glucose metabolism disorders and metabolic syndrome	Baseline

Trial Locations

Locations (1)

Coxa, Hospital for Joint Replacement; 🇫🇮 Tampere, Finland