Determinants of Perioperative Hyperglycaemia in Primary Hip and Knee Replacement
试验速览
- 阶段
- 不适用
- 状态
- 已完成
- 发起方
- 入组人数
- 193
- 试验地点
- 1
- 主要终点
- Occurrence (and severity) of hyperglycemia following primary hip or knee replacement
研究概览
简要总结
The purpose of this study is to analyze how common stress hyperglycaemia (abnormally high blood glucose) is in primary hip and knee replacement surgeries and which factors predispose to hyperglycaemia.
详细描述
Postoperative infections remain one of the most frequent reasons of failure of hip and knee prostheses. Diabetes increases the risk of infections. In other fields of surgery, hyperglycemia induced by surgical stress (stress/perioperative hyperglycemia) has been associated with higher rates of postoperative infections and complications. Such studies have not yet been performed in the field of joint replacement surgery. Unlike several other risk factors of infected joint replacements, hyperglycemia is potentially modifiable and therefore its prevalence, predisposing factors and association with postoperative infections are of interest.
研究设计
- 研究类型
- Observational
- 观察模型
- Cohort
- 时间视角
- Prospective
入排标准
- 年龄范围
- 18 Years 至 —（Adult, Older Adult）
- 性别
- All
- 接受健康志愿者
- 否
入选标准
- •Diagnosis of osteoarthritis
- •Scheduled for primary hip or knee replacement
排除标准
- •Arthritis other than osteoarthritis
- •Medication affecting glucose metabolism (excl. antidiabetic agents)
- •Not undergoing hip or knee replacement
结局指标
主要结局
Occurrence (and severity) of hyperglycemia following primary hip or knee replacement
时间窗: 3 days (average)
Follow-up covers postoperative hospital stay at the operating hospital, that lasts typically 2-5 days.
次要结局
- Incidence of surgical-site infections(1 year)
- Prevalence of glucose metabolism disorders and metabolic syndrome(Baseline)
研究者
Esa Jamsen
MD, PhD, Researcher
Coxa, Hospital for Joint Replacement