Epicardial Adipose Tissue and Arterial Stiffness in People Living With Diabetes (METAB-CV-PWV)
- Conditions
- Diabetic Patients
- Registration Number
- NCT05681533
- Lead Sponsor
- Assistance Publique - Hôpitaux de Paris
- Brief Summary
The present study is a retrospective and prospective current care cohort that will allow us to evaluate the relationship between epicardial fat volume and increased arterial stiffness in a person living with diabetes.
- Detailed Description
Epicardial adipose tissue is considered as the cardiac visceral fat and is associated with increased cardiovascular risk, for example in diabetes. Thus, the mechanisms involved seem to be related to myocardial lipotoxicity; atherosclerosis in connection with inflammation and secretion of proinflammatory factors such as cytokines but also insulin resistance.
In this context, the investigators hypothesize that epicardiac adipose tissue volume will be higher in patients with increased arterial stiffness than in those without. In this study, the investigators will then try to verify the existence of a relationship between pericardial adipose tissue volume and increased arterial stiffness in people living with diabetes.
To do this, the investigators will analyze the results of measurements of pericardial fat volume, coronary calcium score, and pulse wave velocity in diabetic patients.
Recruitment & Eligibility
- Status
- RECRUITING
- Sex
- All
- Target Recruitment
- 400
Patients will be eligible for participation in the study if:
- They are informed and have not objected to participating in the research.
- They have type 1 or 2 diabetes.
- They perform a coronary calcium score measurement by CT scan and a pulse wave velocity assessment during their routine care practice.
Not provided
Study & Design
- Study Type
- OBSERVATIONAL
- Study Design
- Not specified
- Primary Outcome Measures
Name Time Method Epicardial fat volume the inclusion visit Epicardial fat volume will be determined using cardiac CT scan without contrast injection.
- Secondary Outcome Measures
Name Time Method
Trial Locations
- Locations (1)
endocrinologie site, Avicenne hospital
🇫🇷Bobigny, France