Pilot-study: Dexamethasone and function of the HPA axis in children after treatment for Acute Lymphoblastic Leukemia; Relation to sleep

Completed

• Conditions: leukemia sleepproblems; 10024324; 10001353

• Registration Number: NL-OMON35272
• Lead Sponsor: Vrije Universiteit Medisch Centrum

Brief Summary

Not available

Detailed Description

Not available

Study Timeline

• Last Update Posted: 6 May 2024

Recruitment & Eligibility

• Status: Completed
• Sex: Not specified
• Target Recruitment: 150

Inclusion Criteria

- all children that have been treated according to the ALL-9 (VUmc) or ALL-10 (VUmc, WKZ, UMCN) protocol because of acute lymphoblastic leukemie
- fluent in Dutch

Exclusion Criteria

- Down syndrome
- Long-term use of corticosteroids for other reasons than ALL
- other chronic or serious conditions, influencing sleep and/or behavior

Study & Design

• Study Type: Observational non invasive
• Study Design: Not specified

Primary Outcome Measures

Name	Time	Method
<p>Function of the HPA axis will be evaluated with the use of salivatory cortisol<br /><br>and a low-dose dexamethasone suppression test. Information on sleep, fatigue<br /><br>and quality of life will be gathered through questionnaires.</p><br>

Secondary Outcome Measures

Name	Time	Method
<p>not applicable</p><br>