The failure of Proton Pump Inhibitors in Gastro Esophageal Reflux Disease - PPI failure

Academisch Medisch Centrum0 个研究点目标入组 24 人开始时间: 待定最近更新: 2024年5月6日

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•GERD patients with good symptom response to PPI:
•- Written informed consent
•- 18-75 years
•- PPI use of 1-2 daily 40 mg of Omeprazole, Esomeprazole or pantoprazole, or 1-2 daily 30 mg of lansoprazole.
•- GERD confirmed by pH-impedance (ph<4 in > 4,5 % of time or positive symptom association), or in patients with reflux esophagitis.;GERD patients with bad symptom response to PPI:
•- Written informed consent
•- 18-65 years
•- PPI use of 1-2 daily 40 mg of Omeprazole, Esomeprazole or pantoprazole, or 1-2 daily 30 mg of lansoprazole.
•- GERD confirmed by pH-impedance during medication, with a positive symptom association between reflux episodes and symptoms (Symptom Index >50%, or a Symptom Association Probability >95%).

•- surgery of the gastrointestinal tract other then appendectomy
•- inability to stop the use of proton pump inhibitors for one week
•- participation in another study with exposure to radiation within the last year
•- long segment of Barrett*s epithelium

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