Pulmonary Diffusing Capacity During Postural Postural Changes and Acute Exercise

Not Applicable

Completed

• Conditions: Clinical Assessments of Pulmonary Diffusing Capacity
• Interventions: Diagnostic Test: Sitting-to-supine; Diagnostic Test: Rest-to-exercise

• Registration Number: NCT04963504
• Lead Sponsor: Rigshospitalet, Denmark

Brief Summary

The combined measurement of the pulmonary diffusing capacity to carbon monoxide (CO) and nitric oxide (NO) (DLCO/NO) has recently been standardised and validated for clinical use. It involves a very short breath-hold time (≤5 seconds), and it may be repeated up to 12 times without affecting measurements, and it is thus ideal for assessing acute changes in pulmonary diffusing capacity and its components during various physiological manoeuvres. The aim of the present study is to compare the test-retest reliability of pulmonary diffusing capacity measurements during postural changes (sitting vs. supine) vs. rest-to-exercise. DLCO/NO will either be measured in the sitting position during rest vs. exercise or in the sitting and supine posture, and this will be repeated within 1-7 days in 20 healthy individuals that will be randomised to one of the two interventions. Statistically,the test-retest relaibility of sitting-to-supine vs. rest-to-exercise changes in DLCO/NO will be compared by parametric methods.

Detailed Description

Not available

Study Timeline

• Study First Submitted: 2021-07-05
• Study Start: 2021-07-12
• Study First Submitted QC: 2021-07-14
• Study First Posted: 2021-07-15
• Primary Completion: 2021-09-30
• Study Completion: 2021-10-30
• Status Verified: 2021-11
• Last Update Submitted: 2021-11-09
• Last Update Posted: 2021-11-10

Recruitment & Eligibility

• Status: COMPLETED
• Sex: All
• Target Recruitment: 20

Inclusion Criteria

• Regular exercise (1-3 timer per week)

Exclusion Criteria

• Any known medical condition that requires regular medication or any known lung condition
• Smoking
• Symptoms of disease within 2 weeks prior to the study
• Abnormal lung function test
• Pregnancy

Study & Design

• Study Type: INTERVENTIONAL
• Study Design: PARALLEL

Arm && Interventions

Group	Intervention	Description
Sitting-to-supine	Sitting-to-supine	-
Rest-to-exercise	Rest-to-exercise	-

Primary Outcome Measures

Name	Time	Method
Between intervention DLNO/DLCO-ratio repeatability coefficient	1 week	Test-retest reliability coefficient of rest-to-exercise and supine-to-prone DLNO/DLCO-ratio
Between intervention DLCO repeatability coefficient	1 week	Test-retest repeatability coefficient of rest-to-exercise and supine-to-prone DLCO
Between intervention DLNO repeatability coefficient	1 week	Test-retest repeatability coefficient of rest-to-exercise and supine-to-prone DLNO

Secondary Outcome Measures

Name	Time	Method
Between intervention DM repeatability coefficient	1 week	Test-retest repeatability coefficient of rest-to-exercise and supine-to-prone DM
Between intervention Vc repeatability coefficient	1 week	Test-retest repeatability coefficient of rest-to-exercise and supine-to-prone Vc

Trial Locations

Locations (1)

Rigshospitalet; 🇩🇰 Copenhagen, Denmark