Correlation Between Follicular Fluid Levels of Bioavailable Vitamin D and Embryo Quality Markers: Euploid Status, Morphokinetics and Mitochondrial DNA Content Among UAE Women Undergoing an IVF Cycle
试验速览
- 阶段
- 不适用
- 状态
- 已完成
- 入组人数
- 43
- 试验地点
- 1
- 主要终点
- Vitamin D values in follicular fluid and embryo quality markers among UAE women undergoing an IVF cycle
研究概览
简要总结
To determine the correlation between bioavailable Vitamin D values and euploid status of the embryos in larger size follicles from UAE women undergoing in vitro fertilization procedures.
详细描述
To study the possible correlation between bioavailable vitamin D values in follicular fluid and embryo quality markers.
To correlate bioavailable Vitamin D values in follicular fluid from large size follicles with embryo euploid status as our main objective. Secondly, looking at morphokinetics and mitochondrial content of these embryos.
Taking into account that most of UAE patients have deficiency or insufficiency of Vitamin D, if there is a correlation found we will understand better the underlying mechanism by which bioavailable Vitamin D levels may be affecting embryo quality, therefore IVF outcomes.
研究设计
- 研究类型
- Observational
- 观察模型
- Other
- 时间视角
- Prospective
入排标准
- 年龄范围
- 18 Years 至 48 Years（Adult）
- 性别
- Female
- 接受健康志愿者
- 是
入选标准
- •Women´s Age >18 - ≤43 years.
- •BMI 19-33
- •Male partner will produce fresh sperm sample on the same day of the egg collection procedure.
- •Women with more than 10 follicles at the time of the trigger
- •At the time of egg retrieval, at least three follicles between 14-<17 mm and three follicles ≥17 mm.
- •Women ≤35 years old stimulation with rFSH antagonist
- •Women ≥36 years old stimulation with highly-purified human menopausal gonadotropins (hpHMG) specifically for the additional LH.
- •Middle East population
排除标准
- •Polycystic ovarian syndrome (according to the Rotterdam Criteria).
- •Patients at risk of OHSS, according to the criteria previously described by Papanikolau et al. (23).
- •History of endometriosis, classified according to the American Fertility Society (AFS) as stage 3 or more.
- •Severe male factor definition (<2 million of sperm per ml of ejaculate)
- •Recurrent miscarriage (3 miscarriages)
- •History of chemotherapy or radiotherapy
结局指标
主要结局
Vitamin D values in follicular fluid and embryo quality markers among UAE women undergoing an IVF cycle
时间窗: 6-10 months
A correlation between vitamin D levels and embryo development patterns
次要结局
未报告次要终点
研究者
Prof Dr. Human Fatemi
Medical Director
ART Fertility Clinics LLC