A Validation Study of The Relationship Between ALDH2 and Aortic Dissection
- Conditions
- Aortic Dissection
- Registration Number
- NCT03780738
- Lead Sponsor
- Qilu Hospital of Shandong University
- Brief Summary
The purpose of this study is to validate the impact of ALDH2 Glu504Lys polymorphism on aortic dissection.
- Detailed Description
Not available
Recruitment & Eligibility
- Status
- UNKNOWN
- Sex
- All
- Target Recruitment
- 200
Inclusion Criteria
- Chinese Han people diagnosed with aortic dissection in Guangdong Provincial People's Hospital
Exclusion Criteria
- Aortic dissection based on trauma, connective tissue diseases and pregnancy
- Patients with tumor
- Patients with no written consensus
Study & Design
- Study Type
- OBSERVATIONAL
- Study Design
- Not specified
- Primary Outcome Measures
Name Time Method Number of patients with different ALDH2 genotype 1-30 days after samples collected DNA was extracted from venous blood;genomic DNA underwent PCR amplification; finally, PCR products were purified and directly sequenced by Invitrogen Corp or Biosune Corp.Then ALDH2 genotype was distinguished depend on a G-to-A missense mutation on exon 12 of ALDH2 gene.
- Secondary Outcome Measures
Name Time Method
Trial Locations
- Locations (1)
Guangdong Provincial People's Hospital
🇨🇳Guanzhou, Guangdong, China