on-invasive cerebellar stimulation for focal dystonia

Not Applicable

Recruiting

• Conditions: Focal Dystonia; Neurological - Other neurological disorders

• Registration Number: ACTRN12612000339853
• Lead Sponsor: ynley Bradnam

Brief Summary

Not available

Detailed Description

Not available

Study Timeline

• Results First Posted: 1900-01-01
• Study Start: 2012-03-23
• Last Update Posted: 13 January 2020

Recruitment & Eligibility

• Status: Recruiting
• Sex: All
• Target Recruitment: 16

Inclusion Criteria

Over 18 years of age,
Diagnosis of Primary Focal Dystonia by a neurologist
No contraindications to TMS or TDCS (head injury, epilepsy, implanted devices, some medications)
No other neurological or musculoskeletal disorder affecting the dystonic region

Exclusion Criteria

Condtraindications to TMS or TDCS
Musculoskeletal or neurological disorders other than primay focal dystonia affecting the body part
Secondary Dystonia (eg after stroke or Parkinsons Disease)
Generalised Dystonia

Study & Design

• Study Type: Interventional
• Study Design: Not specified

Primary Outcome Measures

Name	Time	Method
europhysiological measures using Transcranial Magnetic Stimulation (TMS). TMS is used to test excitability of intracortical brain circuits, that are known to be affected in primary focal dystonia. A change in these measures more toward 'normal' (as measured by comparison to a healthy group) will indicate improvement.[Immediately post treatment]

Secondary Outcome Measures

Name	Time	Method
Handwriting and circle drawing tasks will be used to assess kinematics before and after the intervention. An improvement in these tasks is expected. The measures of interest include stroke frequency, mean pen pressure and the Coefficient of Variation of positive velocity peaks (CV). These are calculated using computer software. The Handwriting task will also be analysed using the Writers Cramp Rating Scale (WCRS) by an independent assesor.[Immediately post treatment]