Immuno-virological Characterization of Severe H1N1v Influenza Infection in Bronchoalveolar Lavage in Patients Requiring Mechanical Ventilation in Intensive Care Unit
试验速览
- 阶段
- 不适用
- 状态
- 已完成
- 发起方
- 入组人数
- 30
- 试验地点
- 2
- 主要终点
- immunological parameters in blood and bronchoalveolar lavage fluid
研究概览
简要总结
The influenza A/H1N1v pandemic virus causes severe pneumonia that can lead to acute respiratory distress syndrome and death even in healthy young individuals. The respective roles of viral replication, bacterial infection and immune alterations of the host during such severe influenza H1N1v infection need to be clarified in order to optimize patients care. In this context, we aim to study immune and virological parameters in bronchoalveolar lavage fluid during severe influenza A/H1N1v infection with pulmonary involvement in intensive care unit. Results will be correlated to bacterial or viral pulmonary co-infections and to peripheral blood immune and virological parameters.
研究设计
- 研究类型
- Observational
- 观察模型
- Case Control
- 时间视角
- Prospective
入排标准
- 年龄范围
- 13 Years 至 —（Child, Adult, Older Adult）
- 性别
- All
- 接受健康志愿者
- 否
入选标准
- •Suspected influenza A/H1N1 infection
- •Diffuse bilateral pneumonia <96h with acute lung injury or respiratory distress syndrome
- •Invasive or non-invasive ventilation in intensive care unit
- •Age > 13
排除标准
- •Other cause identified of acute lung injury or acute respiratory distress syndrome
- •Contraindicated bronchoalveolar lavage
结局指标
主要结局
immunological parameters in blood and bronchoalveolar lavage fluid
时间窗: day 0 and day 5-7 of ventilation for both blood and BAL, day 30 and month 5 for blood
次要结局
- virological parameters in nose, broncho-alveolar lavage and peripheral blood(day 0 and day 5-7 of ventilation)