Surgical Treatment of Hypertrophic Obstructive Cardiomyopathy With Severe Mitral Insufficiency.
- Conditions
- Hypertrophic Obstructive Cardiomyopathy
- Registration Number
- NCT02054221
- Lead Sponsor
- Meshalkin Research Institute of Pathology of Circulation
- Brief Summary
Compare the results of reconstruction and mitral valve replacement in the surgical treatment of obstructive hypertrophic cardiomyopathy with severe mitral insufficiency.
- Detailed Description
Many years myoectomy for Morrow was the gold standard in the treatment of obstructive hypertrophic cardiomyopathy. Currently more retrospective data in the literature about the good results the extended septal myectomy. But the question remains what is best for patients with obstructive hypertrophic cardiomyopathy and severe mitral insufficiency: use extended myoectomy with mitral valve repair a or replacement.
Recruitment & Eligibility
- Status
- COMPLETED
- Sex
- All
- Target Recruitment
- 82
- Able to sign Informed Consent and Release of Medical Information forms
- Age ≥ 18 years
- obstructive hypertrophic cardiomyopathy
- surgically significant mitral insufficiency
- II-IV (NYHA),
- average systolic pressure gradient greater than 50 mm Hg. Art. at rest;
- basal or medium ventricular obstruction
- Related defect of the aortic valve;
- Organic mitral valve disease (dysplasia, rheumatic fever, infective endocarditis);
- Surgically significant coronary artery lesions;
- Patients requiring implantation of a cardioverter-defibrillator
Study & Design
- Study Type
- INTERVENTIONAL
- Study Design
- CROSSOVER
- Primary Outcome Measures
Name Time Method The function of the mitral valve (mitral regurgitation return, prosthesis dysfunction) one year
- Secondary Outcome Measures
Name Time Method The pressure gradient in the output section of the left ventricle one year
Related Research Topics
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Trial Locations
- Locations (1)
Novosibirsk State Research Institute of Circulation Pathology
🇷🇺Novosibirsk, Novosibirsk territory, Russian Federation
Novosibirsk State Research Institute of Circulation Pathology🇷🇺Novosibirsk, Novosibirsk territory, Russian Federation