Effect of Hebal and Synthetic Medicamentss on Enterococcus Feacalis
- Conditions
- Effective Intracanal Medicaments Against Enterococcus Faecalis
- Interventions
- Dietary Supplement: curcuminDietary Supplement: olive leaves extract
- Registration Number
- NCT06006663
- Lead Sponsor
- Tanta University
- Brief Summary
this study aims to evaluate the antimicrobial efficacy of two synthetic (Ibuprofen, Modified triple antibiotic paste) and two herbal materials (Curcumin and Olive leaves extract) used as intracanal medication, against E.Faecalis in secondary endodontic infection cases.
- Detailed Description
we evaluate the antimicrobial efficacy of two synthetic (Ibuprofen, Modified triple antibiotic paste) and two herbal materials (Curcumin and Olive leaves extract) used as intracanal medication, against E.Faecalis in secondary endodontic infection cases by taking three samples from root canal , the first sample after removing gutta percha from root canal system, the second sample after shaping with protaper universal files and cleaning with 2.5% sodium hypochlorite , the third sample after 7 days from application of the medication .
samples will be diluted into ten fold serial dilution and then the diluted samples will be cultured on bile esculin agar as it is selective media for enterococcus feacalis.
bacterial reduction will be determined and comparision will be made .
Recruitment & Eligibility
- Status
- NOT_YET_RECRUITING
- Sex
- All
- Target Recruitment
- 32
- Single rooted teeth.
- Teeth have clinical signs and symptoms of endodontic failure as sensitivity to percussion, pain, swelling or fistula.
- Teeth with radiographic features of endodontic failure as persistent periapical lesion or widening of periodontal ligament.
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• Teeth with fractures of the crown or root.
- Teeth with periodontal pocket deeper than 4mm.
- Teeth have procedural error like ledge, broken instrument, or perforation.
Study & Design
- Study Type
- INTERVENTIONAL
- Study Design
- PARALLEL
- Arm && Interventions
Group Intervention Description group 1 Ibuprofen 400 mg. ibuprofen as intracanal medicament group 2 modified triple antibiotic paste modified triple antibiotic paste as intracanal medicament group 3 curcumin curcumin as intracanal medicament group 4 olive leaves extract olive leaves as intracanal medicament
- Primary Outcome Measures
Name Time Method measurment of microbial reduction as result of applying synthetic and herbaal intracanal medicaments time necessary for incubation of each sample is 24 hour sample 1 will be taken after gutta percha removal sample 2 will be taken after cleaning and shaping sample 3 will be taken after apllying the intracanal medicament for one week
- Secondary Outcome Measures
Name Time Method
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