Antimicrobial Efficacy of Synthetic Versus Herbal Intracanal Medicaments Against Enterococcus Faecalis
试验速览
- 阶段
- 2 期
- 状态
- 尚未招募
- 入组人数
- 32
- 主要终点
- measurment of microbial reduction as result of applying synthetic and herbaal intracanal medicaments
研究概览
简要总结
this study aims to evaluate the antimicrobial efficacy of two synthetic (Ibuprofen, Modified triple antibiotic paste) and two herbal materials (Curcumin and Olive leaves extract) used as intracanal medication, against E.Faecalis in secondary endodontic infection cases.
详细描述
we evaluate the antimicrobial efficacy of two synthetic (Ibuprofen, Modified triple antibiotic paste) and two herbal materials (Curcumin and Olive leaves extract) used as intracanal medication, against E.Faecalis in secondary endodontic infection cases by taking three samples from root canal , the first sample after removing gutta percha from root canal system, the second sample after shaping with protaper universal files and cleaning with 2.5% sodium hypochlorite , the third sample after 7 days from application of the medication .
samples will be diluted into ten fold serial dilution and then the diluted samples will be cultured on bile esculin agar as it is selective media for enterococcus feacalis.
bacterial reduction will be determined and comparision will be made .
研究设计
- 研究类型
- Interventional
- 分配方式
- Randomized
- 干预模型
- Parallel
- 主要目的
- Treatment
- 盲法
- Single (Participant)
入排标准
- 性别
- All
- 接受健康志愿者
- 是
入选标准
- •Single rooted teeth.
- •Teeth have clinical signs and symptoms of endodontic failure as sensitivity to percussion, pain, swelling or fistula.
- •Teeth with radiographic features of endodontic failure as persistent periapical lesion or widening of periodontal ligament.
排除标准
- •• Teeth with fractures of the crown or root.
- •Teeth with periodontal pocket deeper than 4mm.
- •Teeth have procedural error like ledge, broken instrument, or perforation.
研究组 & 干预措施
group 1
ibuprofen as intracanal medicament
干预措施: Ibuprofen 400 mg. (Drug)
group 2
modified triple antibiotic paste as intracanal medicament
干预措施: modified triple antibiotic paste (Drug)
group 3
curcumin as intracanal medicament
干预措施: curcumin (Dietary Supplement)
group 4
olive leaves as intracanal medicament
干预措施: olive leaves extract (Dietary Supplement)
结局指标
主要结局
measurment of microbial reduction as result of applying synthetic and herbaal intracanal medicaments
时间窗: time necessary for incubation of each sample is 24 hour
sample 1 will be taken after gutta percha removal sample 2 will be taken after cleaning and shaping sample 3 will be taken after apllying the intracanal medicament for one week
次要结局
未报告次要终点
研究者
Alaa Essam Ahmed Abo Laimon
Demonstrator , Endodontic department,Faculty of dentistry,Tanta university
Tanta University