A randomized controlled trial comparing renoprotective effect of conventional diuretics (furocemide and potassium canrenoate) with carperitide and conventional diuretics alone in liver transplant recipients.
Phase 2
- Conditions
- liver transplantation recipients
- Registration Number
- JPRN-C000000329
- Lead Sponsor
- The Artificial Organ and Transplantation Division, Department of Surgery
- Brief Summary
Not available
- Detailed Description
Not available
Recruitment & Eligibility
- Status
- Complete: follow-up complete
- Sex
- All
- Target Recruitment
- 50
Inclusion Criteria
Not provided
Exclusion Criteria
Exclusion criteria 1) Patients on chronic hemo-dialysis. 2) Patients who required hemo-dialysis prior to transplantation. (Includes the use of continuous hemo-diafiltration for treating hepatic coma in fulminant hepatic failure) 3) Patients with underlying complications such as diabetes, hypertension, heart disease, hepatopulmonary syndrome, pulmonary hypertension etc. 4) Patients with renal disease other than hepatorenal syndrome. 5) Patients with contraindicated conditions for the use of studied agent such as pheochromocytoma, epilepsy, and right ventricle infarction. 6) Those that are considered ineligible by the participating physician.
Study & Design
- Study Type
- Interventional
- Study Design
- Not specified
- Primary Outcome Measures
Name Time Method The number (rate) of cases requiring induction of hemo-dialysis due to insufficient diuresis fulfilling the following criteria. 1)Serum creatinine of >6.0mg/dl 2)Oliguria(1ml/kg/hr)lasting over 6hours 3)Serum potassium of > 6.0mEq/l
- Secondary Outcome Measures
Name Time Method 1)Body weight 2)Blood pressure, pulse rate, urine volume 3)Serum creatinine, urea nitrogen 4)Serum atrial natriuretic peptide, aldosterone, brain natriuretic peptide, cyclic GMP 5)Serum renin activity 6)Urine creatinine 7)Urine NAG 8)Urine L-FABP 9)creatinine clearance