The effect of oral simvastatin on the outcome of patients with severe traumatic brain injury
Phase 3
- Conditions
- Severe traumatic brain injury.
- Registration Number
- IRCT20180802040668N1
- Lead Sponsor
- Sari University of Medical Sciences
- Brief Summary
Not available
- Detailed Description
Not available
Recruitment & Eligibility
- Status
- Complete
- Sex
- All
- Target Recruitment
- 98
Inclusion Criteria
Patients with severe traumatic brain injury
Non-use of corticosteroids and statins and NSAIDs
Not having an allergy to statins
Not having a history of autoimmune, cardio, respiratory, neuromuscular, liver or kidney disease
Exclusion Criteria
Space-occupying lesion in the skull, including hematoma and ...
GCS higher than 8 or GCS = 3 on admission
Age> 60 and <18 years
Syndrome organ trauma that requires surgical intervention.
trauma of the limbs that requires surgical intervention.
History of poisoning or drug use
sepsis during the first 72 hours of admission
Study & Design
- Study Type
- interventional
- Study Design
- Not specified
- Primary Outcome Measures
Name Time Method GCS, APACHEE2, ISS. Timepoint: The beginning of the study, Day 3 and Day 10 after starting treatment. Method of measurement: questionnaire.
- Secondary Outcome Measures
Name Time Method