Biomarkers of Renal Dysfunction in Neuroblastoma Survivors

Active, not recruiting

• Conditions: Neuroblastoma Survivors
• Interventions: Other: Urine sample

• Registration Number: NCT03947346
• Lead Sponsor: Memorial Sloan Kettering Cancer Center

Brief Summary

The main purpose of this study is to learn more about biomarkers of kidney function in the blood and urine of neuroblastoma survivors. A biomarker is a biological molecule found in blood, urine, other body fluids, or tissues that is a sign of a normal or abnormal process, or of a condition or disease. A biomarker may be used to see how well the body responds to a treatment for a disease or condition.

Detailed Description

Not available

Basic Information
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Recruitment & Eligibility
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Study & Design
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Trial Locations

Study Timeline

• Study Start: 2019-05-09
• Study First Submitted: 2019-05-09
• Study First Submitted QC: 2019-05-09
• Study First Posted: 2019-05-13
• Status Verified: 2024-03
• Last Update Submitted: 2024-03-18
• Last Update Posted: 2024-03-19
• Primary Completion: 2025-05
• Study Completion: 2025-05

Recruitment & Eligibility

• Status: ACTIVE_NOT_RECRUITING
• Sex: All
• Target Recruitment: 28

Inclusion Criteria

• Diagnosis of neuroblastoma between 0-18 years of age
• < 21 years of age at time of study enrollment
• Two or more years from completion of systemic chemotherapy and/or radiation therapy

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Exclusion Criteria

• Patients treated with observation only
• Patients with multiple primary cancers

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Study & Design

• Study Type: OBSERVATIONAL
• Study Design: Not specified

Arm && Interventions

Group	Intervention	Description
survivors of neuroblastoma treated with nephrotoxic therapy	Urine sample	Upon enrollment, all subjects will receive a urine collection kit by mail. Participants will bring in a first-morning urine specimen on the day of their routinely scheduled long-term follow-up visit, and will then have an additional blood and urine sample drawn with their other clinical care labs upon arrival to MSK.

Primary Outcome Measures

Name	Time	Method
indicators of renal injury	2 years	urine collected from the first morning void will be used to assess urine creatinine

Trial Locations

Locations (1)

Memorial Sloan Kettering Cancer Center; 🇺🇸 New York, New York, United States