Effects of a 12-week Dairy-based Probiotic Dietary Intervention on Cognitive Performance, Emotional Well-being, and Inflammation in Older Adults
试验速览
- 阶段
- 不适用
- 状态
- 已完成
- 入组人数
- 47
- 试验地点
- 4
- 主要终点
- Change in Processing Speed from Baseline to 12-weeks
研究概览
简要总结
The purpose of this study was to determine the effect of dairy-based probiotics on cognitive function, emotional wellbeing, and inflammation. Subjects were assigned to either consume 6 oz of yogurt/day or abstain from consuming yogurt and other probiotic-containing foods for 12 weeks. Subjects completed baseline testing and 12-week follow-up testing consisting of a laboratory blood draw to assess inflammatory biomarkers, and a computerized assessment to evaluate cognitive and emotional wellbeing measures.
研究设计
- 研究类型
- Interventional
- 分配方式
- Randomized
- 干预模型
- Parallel
- 主要目的
- Supportive Care
- 盲法
- None
入排标准
- 年龄范围
- 50 Years 至 —（Adult, Older Adult）
- 性别
- All
- 接受健康志愿者
- 是
入选标准
- •ability to participate in a 12-week study
- •at least 50 years of age
- •not currently taking a probiotic dietary supplement
- •willing to refrain from consuming probiotic dietary supplements or fermented foods for 12-weeks
- •willing to have blood drawn twice
- •willing to consume yogurt daily for 12 weeks
排除标准
- 未提供
研究组 & 干预措施
Control
Subjects were asked to avoid consuming fermented foods for 12 weeks.
Yogurt
Subjects were asked to consume 6 oz. of yogurt daily for 12 weeks.
干预措施: Yogurt (Other)
结局指标
主要结局
Change in Processing Speed from Baseline to 12-weeks
时间窗: Change from baseline processing speed test scores at 12 weeks
Subjects completed a battery of computerized cognitive assessments at baseline and 12-weeks, using the NIHToolbox for Assessment of Neurological and Behavioral Function application. Processing Speed was assessed by the Pattern Comparison Processing Speed test.
Change in Executive Function from Baseline to 12-weeks
时间窗: Change from baseline executive function test scores at 12 weeks
Subjects completed a battery of computerized cognitive assessments at baseline and 12-weeks, using the NIHToolbox for Assessment of Neurological and Behavioral Function application. Executive function was assessed by the Flanker Inhibitory Control and Attention Test and the Dimensional Change Card Sort Test.
Change in Episodic Memory from Baseline to 12-weeks
时间窗: Change in baseline episodic memory score at 12 weeks
Subjects completed a battery of computerized cognitive assessments at baseline and 12-weeks, using the NIHToolbox for Assessment of Neurological and Behavioral Function application. Episodic Memory was assessed by the Picture Sequence Memory test.
Change in Attention from Baseline to 12-weeks
时间窗: Change from baseline attention test scores at 12 weeks
Subjects completed a battery of computerized cognitive assessments at baseline and 12-weeks, using the NIHToolbox for Assessment of Neurological and Behavioral Function application. Attention was assessed by the Flanker Inhibitory Control and Attention Test.
Change in Fluid Cognition Composite from Baseline to 12-weeks
时间窗: Change from baseline fluid cognition composite score at 12-weeks
Subjects completed a battery of computerized cognitive assessments at baseline and 12-weeks, using the NIHToolbox for Assessment of Neurological and Behavioral Function application. The fluid cognition composite score was derived from scores on the Flanker Inhibitory Control and Attention Test, Dimensional Change Card Sort Test, Picture Sequence Memory Test, Pattern Comparison Processing Speed Test, and List Sorting Working Memory test.
Change in Working Memory from Baseline to 12-weeks
时间窗: Change from baseline working memory test scores at 12 weeks
Subjects completed a battery of computerized cognitive assessments at baseline and 12-weeks, using the NIHToolbox for Assessment of Neurological and Behavioral Function application. Working Memory was assessed by the List Sorting Working Memory test.
次要结局
- Change in serum interleukin-6 concentration from baseline to 12 weeks(Change from baseline serum interleukin-6 concentration at 12 weeks)
- Change in Social Satisfaction from Baseline to 12-weeks(Change from baseline social satisfaction test scores at 12 weeks)
- Change in Psychological Wellbeing(Change from baseline psychological satisfaction test scores at 12 weeks)
- Change in Negative Affect from Baseline to 12-weeks(Change from baseline negative affect test scores at 12 weeks)
- Change in serum tumor necrosis factor-alpha concentration from baseline to 12 weeks(Change from baseline serum tumor necrosis factor-alpha concentration at 12 weeks)
- Change in serum c-reactive protein concentration from baseline to 12 weeks(Change from baseline serum c-reactive protein concentration at 12 weeks)
研究者
Annie Roe
Principal Investigator
University of Idaho