The Value of Placental Vascularization and Placental Volume in Pregnancy in APLS
- Conditions
- Antiphospholipid Syndrome in Pregnancy
- Interventions
- Diagnostic Test: Ultrasound with Doppler and 3D technology
- Registration Number
- NCT03505840
- Lead Sponsor
- Aljazeera Hospital
- Brief Summary
Antiphospholipid antibodies are autoantibodies directed against phospholipid-binding proteins. Among these groups of antibodies, lupus anticoagulant (LA) and anticardiolipin antibodies (aCL)
- Detailed Description
APLS can be primary when no evidence of autoimmune disease is found, or secondary to autoimmune processes like systemic lupus erythematous (SLE) in a 40% of the cases.
Recruitment & Eligibility
- Status
- UNKNOWN
- Sex
- Female
- Target Recruitment
- 100
Inclusion Criteria
-
Singleton pregnancy.
- Gestational age of 34-37 weeks.
- Pregnant women with antiphospholipid syndrome
Exclusion Criteria
- Twin or multiple pregnancies.
- Congenital fetal anomalies.
- Gestational age of less than 34.
- Gestational age of more than 37.
- Women with placental or umbilical artery anomalies.
- Antepartum hemorrhage (placental abruption, placenta previa and vasa previa).
- Posterior placenta.
- History of rupture of membrane.
- Patient refusal or fall outs.
Study & Design
- Study Type
- OBSERVATIONAL
- Study Design
- Not specified
- Arm && Interventions
Group Intervention Description antiphospholipid group Ultrasound with Doppler and 3D technology pregnant ladies in the third trimester who have antiphospholipid syndrome control group Ultrasound with Doppler and 3D technology pregnant ladies in the third trimester who have no medical disorders with pregnancy
- Primary Outcome Measures
Name Time Method The number of participants who will have impaired placental doppler indices within 2 months
- Secondary Outcome Measures
Name Time Method
Trial Locations
- Locations (1)
Algazeerah
🇪🇬Giza, Egypt