A clinical trial to study the effect of adding dexmedetomidine to ropivacaine scalp block to attenuate the hemodynamic response to skull pin placement in neurosurgical procedures

Phase 1

Not yet recruiting

Conditions: Malignant neoplasm of brain,

Registration Number: CTRI/2019/08/020826

Lead Sponsor: Department Of Anesthesiology and Critical Care

Brief Summary: This will be a prospective randomised double blind placebo control study In this study 60 patients belonging to ASA physical status grading 1 and 2 will be allocated into two groups each group containing 30 patients In group D patients will be recieving 25ml of 0.5 percent ropivacaine with dexmedetomidine 1 microgram per kg and this solution will be made 30ml In group R patients will be recieving 25 ml of 0.5 percent ropivacaine with normal saline and solution will be made 30 ml Heart rate systolic blood pressure diastolic blood pressure and mean arterial pressure are mnoted before skull pin fixation 1 3 5 and 10 min after skull pin fixation Results will be coded after study

Detailed Description: Not available

Recruitment & Eligibility

Status: Not Yet Recruiting

Sex: All

Target Recruitment: 60

Inclusion Criteria

Patients of either sex Patients aged 18 to 65 years American Society of Anesthesiologists physical status grade I and II Patients scheduled for elective neurosurgical procedures under general anesthesia with tracheal intubation.

Exclusion Criteria

Patients with uncontrolled hypertension Patients with preoperative bradycardia, ischemic heart disease, cardiac arrhythmias Patients with severe hepatic and renal disease Patients with past history of craniotomy Patients allergic to study drugs Patients on alpha blockers treatment preoperatively Patient refusal Patient unable to give consent Pregnant women and lactating mothers.

Study & Design

Study Type: Interventional

Study Design: Not specified

Primary Outcome Measures

Name	Time	Method
Heart rate , systolic blood pressure , diastolic blood pressure and mean arterial pressure are measured at different time points following skull pin placement .	Heart rate , systolic blood pressure , diastolic blood pressure and mean arterial pressure are measured at 1 3 5 10 minutes following skull pin placement

Secondary Outcome Measures

Name	Time	Method
2.Number of episodes of hypertension, hypotension, bradycardia and tachycardia	during study period.

Trial Locations

Locations (1): Sri Venkateshwarw Institute Of medical Sciences
🇮🇳
Chittoor, ANDHRA PRADESH, India
Sri Venkateshwarw Institute Of medical Sciences
🇮🇳Chittoor, ANDHRA PRADESH, India
Dr Aloka Samantaray
Principal investigator
9493547653
aloksvims@gmail.com