Impact of Obstructive Sleep Apnea on Covid-19 Outcomes (OSACOVID-19 Study): A Prospective Observational Cohort Study
试验速览
- 阶段
- 不适用
- 发起方
- 入组人数
- 320
- 试验地点
- 3
- 主要终点
- The rate of clinical improvement
研究概览
简要总结
Covid-19 infection is an on-going pandemic with worse diagnosis in adults with comorbid conditions such as hypertension and cardiopulmonary diseases. Obstructive sleep apnea (OSA) is common in those comorbidities and may contribute to worse prognosis for the Covid-19 cases.
详细描述
The investigators' primary aim is to address the association between the high probability of having OSA and Covid-19 outcomes within 28 days of the hospitalization.
Secondary outcomes will be conducting a polysomnography in cases with high probability of having OSA compared to those with low probability, approx. 4 months after the Covid-19 diagnosis, and re-evaluate the association of the verified OSA diagnosis and severity with the outcomes in the first 4 weeks as well as with the outcomes after 4 months.
研究设计
- 研究类型
- Observational
- 观察模型
- Cohort
- 时间视角
- Prospective
入排标准
- 年龄范围
- 18 Years 至 —（Adult, Older Adult）
- 性别
- All
- 接受健康志愿者
- 否
入选标准
- •Adult patients with Covid 19 diagnosis
- •Ability to read and speak
- •Signed informed consent.
排除标准
- •Subjects with limited life expectancy due to advanced renal disease or uncontrolled malignancies
- •Subjects with alcohol dependency
结局指标
主要结局
The rate of clinical improvement
时间窗: 28 days
Defined as a decline of 2 categories from admission on a 7-category ordinal scale
次要结局
- Clinical status - worsening(7, 14, 21, 28 days)
- Clinical status - improvement(7, 14, 21, 28 days)