NCT05389995进行中（未招募）不适用
Assessing the Effects of a Commercial Lemonade Beverage and Potassium Citrate on Urinary Stone Risk Factors
适应症
干预措施
相关药物
试验速览
- 阶段
- 不适用
- 状态
- 进行中（未招募）
- 入组人数
- 10
- 试验地点
- 1
- 主要终点
- urine citrate levels
研究概览
简要总结
To define the effect of crystal light, potassium citrate, or both on urinary stone risk factors in patients with a history of stone and hypocitraturia/low pH
研究设计
- 研究类型
- Interventional
- 分配方式
- Randomized
- 干预模型
- Crossover
- 主要目的
- Treatment
- 盲法
- None
入排标准
- 年龄范围
- 18 Years 至 80 Years（Adult, Older Adult）
- 性别
- All
- 接受健康志愿者
- 否
入选标准
- •Men and women between age 18-80 years
- •Willing to follow experimental protocol
- •Willing to complete 24-hour urine collections (three total)
- •Willing to sign the informed consent form
- •Completed Litholink Collection with blood work with results
- •a. hypocitraturia OR aciduria i. Hypocitraturics must meet definition of < 450 mg/day for men < 550 mg/day for women.
- •b. Low urine pH must be less than 5.6 c. potassium, BUN, creatinine, eGFR and hemoglobin A1c within normal limits
排除标准
- •Patients with severe hypocitraturia < 200 mg/day (men or women)
- •Patients with hyperkalemia, uncontrolled diabetes, chronic kidney disease, adrenal insufficiency, delayed gastric emptying (or drug induced delayed gastric emptying), peptic ulcer disease, or active UTI
- •Patients with distal renal tubular acidosis or medication induced RTA (e.g. carbonic anhydrase inhibitor, topiramate)
- •Members of vulnerable patient populations
- •Allergies to ingredients in crystal light
- •Patients lacking decisional capacity
研究组 & 干预措施
Potassium citrate
Active Comparator
干预措施: Potassium citrate (Drug)
Crystal light
Active Comparator
干预措施: Crystal light (Drug)
Crystal light + potassium citrate
Active Comparator
干预措施: Potassium citrate + crystal light (Drug)
结局指标
主要结局
urine citrate levels
时间窗: Day 7 of week 5
24 hour urine collection
次要结局
未报告次要终点
研究者
Amy Krambeck
Director of the Endourology/Stone Division
Northwestern University
研究点 (1)
Loading locations...
相似试验
已完成
不适用
Effect of Diet Orange Soda on Urinary LithogenicityKidney StonesNephrolithiasisUrolithiasisNCT01330940VA New York Harbor Healthcare System12
Unknown
不适用
Mineral Water for Prevention of Renal StonesCalcium Oxalate UrolithiasisNCT04638166Singapore General Hospital58
已完成
不适用
The Effects of Sports Drinks on Urinary LithogenicityUrolithiasisNCT00381277VA New York Harbor Healthcare System10
已完成
早期 1 期
Effect of a High Citrate Beverage on Urine Chemistry in Urinary Stone DiseaseUrinary StoneNCT04697706NYU Langone Health6
招募中
不适用
Urine and Stool Analysis in Kidney Stone DiseaseUrolithiasisNCT01637506University of British Columbia20