Improvement in Glycemic Response After Bariatric Surgery
试验速览
- 阶段
- 不适用
- 状态
- 招募中
- 入组人数
- 120
- 试验地点
- 3
- 主要终点
- microbiota composition
研究概览
简要总结
decipher the role of microbiota in glycemic response change after bariatric surgery
详细描述
Despite the vast knowledge linking the gut microbiome to metabolism and the glucose response, the relation still remains unclear. hopefully, a deep understanding of the mechanisms underlying metabolic improvement following bariatric surgery will make it possible to identify targets for pharmacological intervention, which will reduce the need for surgery and its risks.
Previous studies have characterized the microbiome after bariatric surgery, but most suffer from methodological limitations.
The current study has the potential to be innovative and make a significant contribution to understanding the mechanisms involved in early metabolic improvement after bariatric surgery.
研究设计
- 研究类型
- Observational
- 观察模型
- Cohort
- 时间视角
- Prospective
入排标准
- 年龄范围
- 18 Years 至 70 Years（Adult, Older Adult）
- 性别
- All
- 接受健康志愿者
- 是
入选标准
- •candidates of bariatric surgery or cholecystectomy
- •age 18-70
- •male/female
排除标准
- •previous bariatric surgery
- •type 1 diabetes
- •antibiotic treatment 3 months prior to the study
- •probiotic treatment 3 months prior to the study
- •chronic disease - gastrointestinal disease, malignancy, psychiatric disorder, endocrinologic disorders
- •any pathologic findings during endoscopy
- •participants who will suffer from a post-operation complication
研究组 & 干预措施
sleeve gastrectomy surgery
participants undergoing sleeve gastrectomy surgery for weight reduction
干预措施: sleeve gastrectomy surgery (Procedure)
gastric bypass surgery
participants undergoing gastric bypass surgery for weight reduction
干预措施: gastric bypass surgery (Procedure)
cholecystectomy
participants undergoing cholecystectomy
干预措施: control (Procedure)
Pancreatectomy
participants undergoing Pancreatectomy
干预措施: Pancreatectomy (Procedure)
结局指标
主要结局
microbiota composition
时间窗: up to 4 years
The microbiota composition will be assessed using the stool samples of the participants.
Glycemic response
时间窗: up to 4 years
The glycemic response will be measured by taking a blood test (glucose) after 12 hours fast and a second blood test (glucose) after an OGTT(oral glucose tolerance test) of 50 g glucose
次要结局
未报告次要终点