Measurement of Glomerular Filtration Rate (GFR) in HIV Patients: Single-center Study Comparing the Accuracy of Estimators of GFR Versus Iohexol Plasma Clearance
- Registration Number
- NCT02522338
- Brief Summary
Cystatin C, a protease inhibitor produced by most nucleated cells, is freely filtered by the kidneys, and its plasma assay reflects the GFR.
Compare, in HIV patients, the predictive performance of 11 formula to estimate GFR based on assay plasma cystatin C with that of the MDRD formulas.
- Detailed Description
Not available
Recruitment & Eligibility
- Status
- COMPLETED
- Sex
- All
- Target Recruitment
- 300
Inclusion Criteria
- Patients infected with HIV, and included in the cohort NADIS
Exclusion Criteria
- Patient with a known allergy
- Patients treated with metformin
- Patients with severe hepatic impairment defined as a TP spontaneously below 50%
- Patients with a history of dysthyroidism
- Patient with active neoplasia other than skin cancer
- Degradation recent (not older than 3 months) in renal function defined as the deterioration of GFR over 25%.
- Estimated GFR less than 15 mL/min/1, 73m2
- Pregnant or lactating
- Subjects under the protection of justice
Study & Design
- Study Type
- INTERVENTIONAL
- Study Design
- SINGLE_GROUP
- Arm && Interventions
Group Intervention Description iohexol plasma clearance iohexol patients had received iohexol for measuring GFR
- Primary Outcome Measures
Name Time Method Patient with a predictive performance range -30% to +30% day 0 for each estimator :predictive performance calculated by \[(DFG estimé\* - DFG mesuré par iohexol\*\*)/DFG mesuré par iohexol\]X100
- Secondary Outcome Measures
Name Time Method
Trial Locations
- Locations (1)
CHU de SAINT-ETIENNE
🇫🇷Saint-etienne, France