Ovarian Hyper Stimulation Syndrome Using Calcium Infusion
Overview
- Phase
- Not Applicable
- Intervention
- Calcium intravenous infsuion
- Conditions
- Ovarian Hyperstimulation Syndrome
- Sponsor
- Al-Azhar University
- Enrollment
- 200
- Primary Endpoint
- OHSS rate
- Last Updated
- 4 years ago
Overview
Brief Summary
the incidence of OHSS and clinical outcomes after calcium IV infusion in high-risk women undergoing ART
Detailed Description
Among assisted reproductive technologies (ART), ovarian hyperstimulation syndrome (OHSS) is a serious iatrogenic complication affects up to 30% of women undergoing ART and caries high risks of morbidity and mortality. Women with age younger than 35 years, those with history of polycystic ovary syndrome (PCOS), or having a history of previous OHSS are more susceptible to develop OHSS
Investigators
Ahmed Said Ali
DR: ahmedsaidali, MCS CANDIDIATE
Al-Azhar University
Eligibility Criteria
Inclusion Criteria
- •infertile women aged 20 to 38 years. BMI ranged from 18 to
- •serum FSH within normal limits( 1-12IU /l) presented with ovarian response suggestive of being at risk of developing OHSS because of the presence of at least 15 follicles of 10 mm or greater on the day of hCG administration.
Exclusion Criteria
- •endocrinopathies. a systemic disease. and Insulin-dependent diabetes Thyroid disease using any medication (e.g., insulin-sensitizing drugs and GnRH antagonists. patients need coasting for high risk of OHSS. patients need cycle cancellation. severe male infertility requiring testicular sperm extraction.
Arms & Interventions
Calcium intravenous infusion
intravenous infusion of 10 % calcium gluconate 10 mL in 200 mL of physiologic saline on the day of ovum pickup, day 1,day 2, and day 3 after ovum pickup were administered in study group. Intravenous infusion was performed within 30 minutes
Intervention: Calcium intravenous infsuion
saline
0.9 % saline intravenous infusion
Intervention: 0.9 % saline
Outcomes
Primary Outcomes
OHSS rate
Time Frame: one year
ovarain hyperstimulation syndrome