Ovarian Hyper Stimulation Syndrome Using Calcium Infusion
试验速览
- 阶段
- 不适用
- 入组人数
- 200
- 主要终点
- OHSS rate
研究概览
简要总结
the incidence of OHSS and clinical outcomes after calcium IV infusion in high-risk women undergoing ART
详细描述
Among assisted reproductive technologies (ART), ovarian hyperstimulation syndrome (OHSS) is a serious iatrogenic complication affects up to 30% of women undergoing ART and caries high risks of morbidity and mortality. Women with age younger than 35 years, those with history of polycystic ovary syndrome (PCOS), or having a history of previous OHSS are more susceptible to develop OHSS
研究设计
- 研究类型
- Interventional
- 分配方式
- Randomized
- 干预模型
- Parallel
- 主要目的
- Treatment
- 盲法
- Quadruple (Participant, Care Provider, Investigator, Outcomes Assessor)
入排标准
- 年龄范围
- 18 Years 至 45 Years（Adult）
- 性别
- Female
- 接受健康志愿者
- 否
入选标准
- •infertile women aged 20 to 38 years. BMI ranged from 18 to
- •serum FSH within normal limits( 1-12IU /l) presented with ovarian response suggestive of being at risk of developing OHSS because of the presence of at least 15 follicles of 10 mm or greater on the day of hCG administration.
排除标准
- •endocrinopathies. a systemic disease. and Insulin-dependent diabetes Thyroid disease using any medication (e.g., insulin-sensitizing drugs and GnRH antagonists. patients need coasting for high risk of OHSS. patients need cycle cancellation. severe male infertility requiring testicular sperm extraction.
研究组 & 干预措施
Calcium intravenous infusion
intravenous infusion of 10 % calcium gluconate 10 mL in 200 mL of physiologic saline on the day of ovum pickup, day 1,day 2, and day 3 after ovum pickup were administered in study group.
Intravenous infusion was performed within 30 minutes
干预措施: Calcium intravenous infsuion (Drug)
saline
0.9 % saline intravenous infusion
干预措施: 0.9 % saline (Drug)
结局指标
主要结局
OHSS rate
时间窗: one year
ovarain hyperstimulation syndrome
次要结局
未报告次要终点
研究者
Ahmed Said Ali
DR: ahmedsaidali, MCS CANDIDIATE
Al-Azhar University