Ovarian Hyperstimulation Syndrome Using Calcium Infusion
Not Applicable
- Conditions
- Ovarian Hyperstimulation Syndrome
- Interventions
- Drug: 0.9 % saline
- Registration Number
- NCT05198128
- Lead Sponsor
- Al-Azhar University
- Brief Summary
the incidence of OHSS and clinical outcomes after calcium IV infusion in high-risk women undergoing ART
- Detailed Description
Among assisted reproductive technologies (ART), ovarian hyperstimulation syndrome (OHSS) is a serious iatrogenic complication affects up to 30% of women undergoing ART and caries high risks of morbidity and mortality. Women with age younger than 35 years, those with history of polycystic ovary syndrome (PCOS), or having a history of previous OHSS are more susceptible to develop OHSS
Recruitment & Eligibility
- Status
- UNKNOWN
- Sex
- Female
- Target Recruitment
- 200
Inclusion Criteria
- infertile women aged 20 to 38 years. BMI ranged from 18 to 40. serum FSH within normal limits( 1-12IU /l) presented with ovarian response suggestive of being at risk of developing OHSS because of the presence of at least 15 follicles of 10 mm or greater on the day of hCG administration.
Exclusion Criteria
- endocrinopathies. a systemic disease. and Insulin-dependent diabetes Thyroid disease using any medication (e.g., insulin-sensitizing drugs and GnRH antagonists. patients need coasting for high risk of OHSS. patients need cycle cancellation. severe male infertility requiring testicular sperm extraction.
Study & Design
- Study Type
- INTERVENTIONAL
- Study Design
- PARALLEL
- Arm && Interventions
Group Intervention Description Calcium intravenous infusion Calcium intravenous infsuion intravenous infusion of 10 % calcium gluconate 10 mL in 200 mL of physiologic saline on the day of ovum pickup, day 1,day 2, and day 3 after ovum pickup were administered in study group. Intravenous infusion was performed within 30 minutes saline 0.9 % saline 0.9 % saline intravenous infusion
- Primary Outcome Measures
Name Time Method OHSS rate one year ovarain hyperstimulation syndrome
- Secondary Outcome Measures
Name Time Method