Evaluation and comparison of the preconditioning effect of Remifentanil Vs. Fentanyl on prevalence of early graft dysfunction among patients with liver transplant

Not Applicable

Recruiting

• Conditions: organ transplant.; Surgical operation with transplant of whole organ

• Registration Number: IRCT20141009019470N70
• Lead Sponsor: Shiraz University of Medical Sciences

Brief Summary

Not available

Detailed Description

Not available

Study Timeline

• Results First Posted: 1900-01-01
• Last Update Posted: 21 May 2018

Recruitment & Eligibility

• Status: Recruiting
• Sex: All
• Target Recruitment: 100

Inclusion Criteria

aged 18 to 65 years old
patients who are candidate for liver transplant

Exclusion Criteria

allergy to propofol soy beans and egg
donors with cardio-pulmonary arrest or hemodynamic instability with high doses of inotropes (infusion nor epinephrine above µg/min)
cold ischemia time more than 12 hours.
history of hepatopulmonary syndrome
history of portopulmonary hypertension
renal insufficiency (Cr > 1.5 mg/L)

Study & Design

• Study Type: interventional
• Study Design: Not specified

Primary Outcome Measures

Name	Time	Method
Aspartate transaminase (AST), Alanine transaminase (ALT), Alkaline phosphatase (Alkp), prothrombin time (PT), partial thrombin time (PTT) international normalized ratio (INR). Timepoint: from day 1 to 7 post-operation. Method of measurement: blood sample.

Secondary Outcome Measures

Name	Time	Method
Blood urea nitrogen (BUN). Timepoint: From day 1 to 7 post-operation. Method of measurement: Blood sample.;Duration of hospital and ICU stay. Timepoint: From day 1 to the day of dicharge. Method of measurement: Observation.;Metabolic acidosis (PH, base excess (BE). Timepoint: From day 1 to 7 post-operation. Method of measurement: Blood sample.;Creatinine (Cr). Timepoint: From day 1 to 7 post-operation. Method of measurement: Blood sample.;Duration of mechanical ventilation. Timepoint: From day 1 to 7 post-operation. Method of measurement: Observation.;Extubation time post- operation. Timepoint: From day 1 to 7 post-operation. Method of measurement: Observation.;Cold and warm ischemia time. Timepoint: Intra-operative. Method of measurement: Observation.;Amount of received blood products during the operation. Timepoint: Intra-operative. Method of measurement: Observation.