Functional near-infrared spectroscopy-based assessment of prefrontal cortical activity in sepsis associated encephalopathy

All India Institute of Medical Sciences1 个研究点分布在 1 个国家目标入组 100 人开始时间: 2026年4月4日最近更新: 2025年11月14日

试验速览

阶段: 不适用
状态: 尚未招募
发起方: All India Institute of Medical Sciences
入组人数: 100
试验地点: 1

研究概览研究设计入排标准研究者研究点记录与标识符相似试验

研究概览

简要总结

This observational study will help in identification of changes in cerebral oxygenation in prefrontal cortex area of patients with sepsis associated encephalopathy which will help to further support the concept that sepsis associated encephalopathy results in declining of functional brain activity.

研究设计

研究类型: Observational

入排标准

年龄范围: 18.00 Year(s) 至 70.00 Year(s)（—）
性别: All

入选标准

•18 to 70 years Admitted to the ICU within 24 hours of having been diagnosed with septic shock defined by Sepsis 3 consensus guidelines as a “Suspected or confirmed source of infection with Sequential organ failure assessment more than or equal to 2 and Shock defined as hypotension requiring persistent vasopressor therapy to maintain mean arterial pressure more than 65 mmHg and serum lactate levels greater than 2 mmol per litre despite adequate initial fluid resuscitation at least 30ml per kilogram of ideal body weight SAE diagnosed with cerebral dysfunction Glasgow Coma Scale less than or equal to 14 or with delirium caused by systemic responses to infections without structural abnormality, cerebral nervous system infection, and encephalopathy due to other causes such as hepatic, uremic, and toxic.

排除标准

•Patients diagnosed with other causes of encephalopathy (hepatic, toxic, uremic, hypoxic) A pre-ICU diagnosis of cognitive dysfunction as indicated by their medical records on admission, or a primary central nervous system diagnosis like a cerebrovascular accident, meningitis, seizure disorder, psychiatric disorder, hypoxic encephalopathy post cardiac arrest.
•Life-threatening bleeding, the presence of hemorrhagic shock, as judged by research or treating clinicians Burns, Pregnancy Referral from or treated at other healthcare facilities Readmission to ICU Withdrawal of consent.

研究者

发起方

All India Institute of Medical Sciences

申办方类型

Government medical college

责任方

Principal Investigator

主要研究者

Santosh Parajuli

All India Institute of Medical Sciences

研究点 (1)

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