Housing, Environment, And Living Conditions for Transformed Health

Not Applicable

Not yet recruiting

• Conditions: Lung Diseases; Chronic Disease

• Registration Number: NCT06925373
• Lead Sponsor: University of Alabama at Birmingham

Brief Summary

This project will compare the health effects of public housing renovation, neighborhood built and social environment improvements, and indoor air purification, alone and in combination, as well as the cost effectiveness of each approach.

STUDY 1: The study will assess the effects of public housing and neighborhood environment (built and social) improvements on health-related behaviors, psychosocial and physiologic stress, and self-reported and physiological markers of lung health and chronic disease.

STUDY 2: The study will determine whether indoor air purification can positively impact lung health in public housing sites not undergoing housing renovation, comparing a site near industrial pollution vs one less contaminated.

Detailed Description

Participants will complete surveys, physical exam, lung function tests, and blood draw. An indoor air purifier with a usage tracker and an indoor air quality monitor will be provided, and used filters will be analyzed.

Study Timeline

• Study First Submitted: 2025-03-11
• Status Verified: 2025-04
• Study First Submitted QC: 2025-04-06
• Study First Posted: 2025-04-13
• Last Update Submitted: 2025-04-20
• Last Update Posted: 2025-04-24
• Study Start: 2025-05-15
• Primary Completion: 2028-07
• Study Completion: 2028-07

Recruitment & Eligibility

• Status: NOT_YET_RECRUITING
• Sex: All
• Target Recruitment: 460

Inclusion Criteria

• Adults age 18 years and older
• English speaking
• Residents of one of 4 public housing site in Birmingham, Alabama

Exclusion Criteria

• Individuals who are not 18 years or older
• Do not speak English
• Do not meet the residency criteria

Study & Design

• Study Type: INTERVENTIONAL
• Study Design: PARALLEL

Primary Outcome Measures

Name	Time	Method
Change in Patient-Reported Outcomes Measurement Information System (PROMIS-10) Global Health	Baseline, 12 months, 24 months	A self-reported measure of physical, mental, and social health. 10 item questionnaire T-score metric from zero to 100 where higher T-scores indicate better health.
Change in Allostatic load	Baseline, 12 months	Measure of cumulative stress burden as the number of 10 indicators above a threshold: (1) serum albumin \<3.8 g/dL, (2) C Reactive Protein (CRP) \>3 mg/L, (3) High-Density Lipoprotein (HDL) \<40 mg/dL, (4) total cholesterol ≥240 mg/dL, (5) heart rate ≥90 beats/min, (6) systolic Blood Pressure (BP) ≥140 mmHg, (7) diastolic BP ≥90 mmHg, (8) serum creatinine ≥1.3 mg/dL, (9) Blood Urea Nitrogen (BUN) ≥18 mg/dL, and (10) waist circumference \>88 cm in women, \>102 cm in men.
Change in Indoor Air Quality	Baseline, 6 months, 12 months (Study 2 only)	Particulate matter (PM2.5). Measures particles in the air that are 2.5 micrometers or smaller in diameter.

Secondary Outcome Measures

Name	Time	Method
The percentage change in FEV1/FVC	Baseline, 6 months, 12 months (Study 2 only)	FEV1/FVC. A measure of lung funtion that compares the amount of air exhaled in the first second (FEV1) to the total amount of air exhaled in a forced breath (FVC).

Trial Locations

Locations (1)

UAB Lung Health Center; 🇺🇸 Birmingham, Alabama, United States