Prognosis Scoring System for Acute-on-Chronic Liver Failure
试验速览
- 阶段
- 不适用
- 发起方
- 入组人数
- 1,000
- 主要终点
- survival rate
研究概览
简要总结
This research is to establish a simple and practical system to predict the prognosis of sever hepatitis B.Seven factors (level of serum total bilirubin, prothrombin time, severity of hepatic encephalopathy, hepatorenal syndrome,ascites ,infection and size of liver) which were easier to evaluate and more influential， were included to establish a prognosis scoring system．The scorings of a new score system and MELD were graded at the same time in the patients with sever hepatitis B. And then the distribution figures of survival rates and mortality rates were done according to the scores from low to high. The features of distribution figures of two score system in survival rates and mortality rates and significances of clinical application in certain score were interpreted.
研究设计
- 研究类型
- Observational
- 观察模型
- Case Only
- 时间视角
- Prospective
入排标准
- 年龄范围
- 18 Years 至 60 Years（Adult）
- 性别
- All
- 接受健康志愿者
- 否
入选标准
- •serum hepatitis B surface antigen(HBsAg) positive for at least 6 months;
- •All patients had a poor general condition, manifested as general malaise, fatigue, jaundice and so on;
- •serum T-Bil of 171 mmol/L or more; or serum T-Bil rises 17.1 mmol/L or more per day;
排除标准
- •superinfection or co-infection with hepatitis A, C, D, E, cytomegalovirus and HIV, or Epstein-Barr virus;
- •other liver diseases such as alcoholic liver disease, drug-induced hepatitis, Wilson disease and autoimmune hepatitis;
- •ascites or gastrointestinal bleeding or peptic ulcer or esophageal varix by electronic gastroscope examination;
- •decompensated liver cirrhosis;
- •severe bacterial or fungal infections;
- •a history of diabetes or cardiac disease or hypertension or nephrosis.
结局指标
主要结局
survival rate
时间窗: twelve weeks
次要结局
未报告次要终点
研究者
Zhe-bin Wu
Principal Investigator
Third Affiliated Hospital, Sun Yat-Sen University