Evaluation of efficacy of ozonated and non-ozonated 2% Chlorhexidine gluconate and 0.1% Octinidine hydrochloride with and without hypochlorite application in single visit endodontic retreatment: A randomised clinical trial.
试验速览
- 阶段
- 不适用
- 状态
- 尚未招募
- 入组人数
- 120
- 试验地点
- 1
- 主要终点
- Pain after secondary endodontic treatment
研究概览
简要总结
**Aim:**To compare the effect of different irrigation regimes on post endodontic pain in patients undergoing single-visit endodontic retreatment, with 2% Chlorhexidine and 0.1% Octinidine with and without ozone and hypochlorite.
Materials and Methods: Adult patients requiring retreatment were selected. Following local anesthesia and isolation, access cavities were modified. Standard retreatment protocol was followed and patients were randomly assigned into groups -
Group 1 - 2% Chlorhexidine with sodium hypochlorite (CHX) (Control group)
Group 2 - 2% Ozonated chlorhexidine without sodium hypochlorite (OCHX).
Group 3 - 2% Ozonated chlorhexidine with sodium hypochlorite (OCHXH).
Group 4 - 0.1% Octinidine with sodium hypochlorite (OCT).
Group 5 - 0.1% Ozonated octinidine without sodium hypochlorite (OOCT).
Group 6 - 0.1% Ozonated octinidine with sodium hypochlorite (OOCTH).
Each group was irrigated with 15 ml of ozonated/non - ozonated irrigant (CHX/ OCT) for 3-5 minutes with ultrasonic agitation. Obturation and core built-up were completed at the same appointment. The level of discomfort at baseline, after 6, 12, 24, 48 hours, and 7 days were recorded on the Visual Analogue Scale. Pain levels were recorded, tabulated, and subjected to statistical analysis using a two-way analysis of variance followed by post hoc Bonferroni test.
研究设计
- 研究类型
- Interventional
- 分配方式
- Computer generated randomization
- 盲法
- Participant and Outcome Assessor Blinded
入排标准
- 年龄范围
- 19.00 Year(s) 至 65.00 Year(s)（—）
- 性别
- All
入选标准
- •Patients with single rooted, root-filled tooth with persistent apical periodontitis / symptomatic teeth with or without lesion requiring endodontic retreatment with radiographic/clinical evidence of previous endodontic treatment and periradicular disease were included in the study were recruited.
- •Other inclusion criteria were endodontic treatment done > 3 years back, sufficient coronal tooth structure for adequate isolation with rubber dam, gutta-percha material within 4–7 mm of the radiographic apex and no direct exposure of root canal filling material to oral cavity.
排除标准
- •Medically compromised patients, patients allergic to the local anesthetic agent/ irrigants/ ozone and patients with recent myocardial infarction, acute alcohol intoxication, active bleeding, uncontrolled hyperthyroidism, thrombocytopenia, glucose 6 phosphatase deficiency (contraindications of ozone therapy) were excluded.
- •Patients under 18 years of age, with swelling and/or acute apical abscess; analgesic/ antibiotic/ corticosteroid / anti-inflammatory taken within the past 7 days before treatment, and multiple teeth (to eliminate the possibility of pain referral), periodontal pocket deeper than 4 mm, intraradicular posts were excluded.
结局指标
主要结局
Pain after secondary endodontic treatment
时间窗: At baseline, after 6, 12, 24, 48 hours, and 7 days
次要结局
- Pain after secondary endodontic treatment(At baseline, after 6, 12, 24, 48 hours, and 7 days)