Evaluation of pain following ozonated chlorhexidine and octinidine irrigation in endodontic retreatment.

Not yet recruiting

• Conditions: Chronic apical periodontitis,

• Registration Number: CTRI/2022/02/040315
• Lead Sponsor: Pacific dental college and hospital

Brief Summary

**Aim:**To compare the effect of different irrigation regimes on post endodontic pain in patients undergoing single-visit endodontic retreatment, with 2% Chlorhexidine and 0.1% Octinidine with and without ozone and hypochlorite.

**Materials and Methods:** Adult patients requiring retreatment were selected. Following local anesthesia and isolation, access cavities were modified. Standard retreatment protocol was followed and patients were randomly assigned into groups -

Group 1 - 2% Chlorhexidine with sodium hypochlorite (CHX) (Control group)

Group 2 - 2% Ozonated chlorhexidine without sodium hypochlorite (OCHX).

Group 3 - 2% Ozonated chlorhexidine with sodium hypochlorite (OCHXH).

Group 4 - 0.1% Octinidine with sodium hypochlorite (OCT).

Group 5 - 0.1% Ozonated octinidine without sodium hypochlorite (OOCT).

Group 6 - 0.1% Ozonated octinidine with sodium hypochlorite (OOCTH).

Each group was irrigated with 15 ml of ozonated/non - ozonated irrigant (CHX/ OCT) for 3-5 minutes with ultrasonic agitation. Obturation and core built-up were completed at the same appointment. The level of discomfort at baseline, after 6, 12, 24, 48 hours, and 7 days were recorded on the Visual Analogue Scale. Pain levels were recorded, tabulated, and subjected to statistical analysis using a two-way analysis of variance followed by post hoc Bonferroni test.

Detailed Description

Not available

Study Timeline

• Study Start: 2022-02-21
• Last Update Posted: 2022-11-02

Recruitment & Eligibility

• Status: Not Yet Recruiting
• Sex: All
• Target Recruitment: 120

Inclusion Criteria

• Patients with single rooted, root-filled tooth with persistent apical periodontitis / symptomatic teeth with or without lesion requiring endodontic retreatment with radiographic/clinical evidence of previous endodontic treatment and periradicular disease were included in the study were recruited.
• Other inclusion criteria were endodontic treatment done > 3 years back, sufficient coronal tooth structure for adequate isolation with rubber dam, gutta-percha material within 4–7 mm of the radiographic apex and no direct exposure of root canal filling material to oral cavity.

Exclusion Criteria

• Medically compromised patients, patients allergic to the local anesthetic agent/ irrigants/ ozone and patients with recent myocardial infarction, acute alcohol intoxication, active bleeding, uncontrolled hyperthyroidism, thrombocytopenia, glucose 6 phosphatase deficiency (contraindications of ozone therapy) were excluded.
• Patients under 18 years of age, with swelling and/or acute apical abscess; analgesic/ antibiotic/ corticosteroid / anti-inflammatory taken within the past 7 days before treatment, and multiple teeth (to eliminate the possibility of pain referral), periodontal pocket deeper than 4 mm, intraradicular posts were excluded.

Study & Design

• Study Type: Interventional
• Study Design: Not specified

Primary Outcome Measures

Name	Time	Method
Pain after secondary endodontic treatment	At baseline, after 6, 12, 24, 48 hours, and 7 days

Secondary Outcome Measures

Name	Time	Method
Pain after secondary endodontic treatment	At baseline, after 6, 12, 24, 48 hours, and 7 days

Trial Locations

Locations (1)

PACIFIC DENTAL COLEGE AND HOSPITAL; 🇮🇳 Udaipur, RAJASTHAN, India

PACIFIC DENTAL COLEGE AND HOSPITAL

🇮🇳Udaipur, RAJASTHAN, India

DR NIDHI SINHA

Principal investigator

08619423478

dr.nidhi.sinha@gmail.com