Effect of Therapeutic Education on Pain Intensity and BDNF Levels in Patients With Chronic Pain
试验速览
- 阶段
- 不适用
- 状态
- 招募中
- 入组人数
- 66
- 试验地点
- 4
- 主要终点
- Pain Intensity
研究概览
简要总结
The promotion of neuroplasticity in conjunction with strategies for restructuring maladaptive cognitions that largely cause the activation of neural networks that contribute to the perpetuation of pain is therefore a fundamental neurophysiological principle for establishing a neurophysiological basis for pain.
perpetuation of pain, is therefore a fundamental neurophysiological principle for establishing physiotherapy therapeutic to establish therapeutic strategies from physiotherapy that contribute to improve the quality of life of patients with chronic pain. patients with chronic pain.
Based on the theory that neurotrophic factors such as BDNF play a fundamental role in the initiation and or maintenance of hyperexcitability of central neurons in pain, we consider that the levels of this neurotrophic factor, such as BDNF, may have an important role in the perpetuation of pain.
that the levels of this neurotrophic factor may be modified by the application of a therapeutic education protocol, favoring therapeutic education protocol, favoring a reduction in pain intensity.
研究设计
- 研究类型
- Interventional
- 分配方式
- Randomized
- 干预模型
- Parallel
- 主要目的
- Treatment
- 盲法
- Quadruple (Participant, Care Provider, Investigator, Outcomes Assessor)
入排标准
- 年龄范围
- 18 Years 至 65 Years（Adult, Older Adult）
- 性别
- All
- 接受健康志愿者
- 否
入选标准
- •males and females aged 18 to 65 years with musculoskeletal pain for a minimum of 3 months
- •patients recruited by information pamphlets from the university clinic of the Rey Juan Carlos University, and CSEU La Salle
- •not having received physiotherapy treatment for this same process in the last 3 months.
- •ability to perform all the clinical tests and to understand the study process, as well as to obtain informed consent.
排除标准
- •Systemic, neurological, oncological or inflammatory diseases; psychiatric pathologies, pregnancy, type II diabetes.
结局指标
主要结局
Pain Intensity
时间窗: 36 weeks
Pain intensity assessed with the 100 mm Visual Analog Scale, in which the patient is asked about his or her pain level at that moment, with one side being "no pain" and the other extreme being "the worst pain imaginable".
次要结局
- Pain Severity Level (GCPS-R)(36 weeks)
- Anxiety and Depression (HADS)(36 weeks)
- Heart rate (HR)(36 weeks)
- BDNF level(36 weeks)
- Oxygen Saturation (SpO2)(36 weeks)
- Quality of life (EQ-5D)(36 weeks)
- Pain Catastrophism (PCS)(36 weeks)
研究者
Raúl Ferrer-Peña
Principal Investigator
Universidad Autonoma de Madrid