Mortality in Cancer Patients Admitted to the Intensive Care Unit in a Resource-limited Setting

Completed

• Conditions: Cancer
• Interventions: Other: Cancer patients admitted to the ICU

• Registration Number: NCT02659839
• Lead Sponsor: Pontificia Universidad Catolica de Chile

Brief Summary

The purpose of this study is to determine 30 day mortality in cancer patients admitted to the intensive care unit in a resource limited setting.

Detailed Description

The management of cancer patients in the intensive care unit (ICU) has changed dramatically during the last two decades. Initial experiences showed high rates of hospital mortality, reaching up to 75-85% in patients requiring life-sustaining treatments, particularly mechanical ventilation. An increasing number of clinical experiences has been reported pointing to a significant improvement in survival of these patients. However, it is not clear if this results are generalizable to settings with resource constraints. Therefore, the purpose of this study is to determine 30 day mortality in cancer patients admitted to the intensive care unit in a resource limited setting.

This study is a prospective cohort of cancer patients admitted to the ICU in which the investigators will evaluate the prognostic of cancer patients admitted for a ICU trial or treatment in ICU without limitations. This study will not consider any change in the treatment plan of the patients. The source of the data will be the clinical records of the patients during the admission and the records of the cancer unit. There will be no direct contact of the research team with the patients or their family.

Study Timeline

• Study Start: 2015-07
• Study First Submitted: 2016-01-16
• Study First Submitted QC: 2016-01-19
• Study First Posted: 2016-01-20
• Status Verified: 2016-10
• Primary Completion: 2016-10
• Study Completion: 2016-10
• Last Update Submitted: 2016-10-26
• Last Update Posted: 2016-10-27

Recruitment & Eligibility

• Status: COMPLETED
• Sex: All
• Target Recruitment: 142

Inclusion Criteria

• 18 years-old or older

• Histological diagnosis or high clinical suspicious of cancer (solid /hematological), with the exception of non-melanoma skin cancer.

• Functional classification state between 0-3, according to Eastern Cooperative Oncology Group.

• Admission to intensive care unit, because of one or more of the following criteria:

  1. Invasive or non-invasive ventilatory support due to acute respiratory failure.
  2. Use of vasopressor drugs due to hypotension defined as noradrenaline requirement higher than 0.1 microgram/Kg/min.
  3. Renal replacement therapy due to acute renal failure.

Exclusion Criteria

• Absence of cancer recurrences in more than 5 years after diagnosis
• Functional classification state of 4, according to Eastern Cooperative Oncology Group.

Study & Design

• Study Type: OBSERVATIONAL
• Study Design: Not specified

Arm && Interventions

Group	Intervention	Description
Cancer patients admitted to the ICU	Cancer patients admitted to the ICU	Patients with cancer admitted to the ICU. No intervention will be administered.

Primary Outcome Measures

Name	Time	Method
Mortality at 30 days	30 days since ICU admission

Secondary Outcome Measures

Name	Time	Method
Mortality at 180 days	180 days since ICU admission

Trial Locations

Locations (1)

Hospital Dr. Sótero del Rio; 🇨🇱 Santiago, Region Metropolitana, Chile