The modulation effect of Qing-Gan Jie-Yu Herbal Formula Granule in Salience Network for migraine patients with liver depression of the heat syndrome: a brain imaging study

Not Applicable

• Conditions: Migraine

• Registration Number: ITMCTR2000003018
• Lead Sponsor: Beijing Hospital of traditional Chinese Medicine Affiliated to Capital Medical University

Brief Summary

Not available

Detailed Description

Not available

Study Timeline

• Results First Posted: 1900-01-01
• Last Update Posted: 20 February 2023

Recruitment & Eligibility

• Status: Pending
• Sex: All
• Target Recruitment: Not specified

Inclusion Criteria

1. To be diagnosed as MWoA;
2. To be considered as the liver depression of the heat syndrome according to liver depression of the heat syndrome diagnosis scale;
3. Aged between 18–50 years and right-handed;
4. Had at least six months of migraine duration;
5. Had not taken any prophylactic medicine during the last three months;
6. Not participating other ongoing clinical studies;
7. Written informed consent was signed.

Exclusion Criteria

1. Be alcohol or drug abusers;
2. Be pregnant or during lactation;
3. Suffered from psychiatric, neurologic, cardiovascular, respiratory or renal illnesses;
4. Suffered from any other chronic pain conditions or had a history of head trauma, with loss of consciousness;
5. Have MRI contraindications, such as claustrophobia;
6. Unable to complete headache diary due to cognitive decline;
7. Be allergic to Chinese medicine herbs.

Study & Design

• Study Type: Interventional study
• Study Design: Not specified

Primary Outcome Measures

Name	Time	Method
functional connectivity of salience network;

Secondary Outcome Measures

Name	Time	Method
Self-Rating Anxiety, SAS;the changes of liver depression of the heat syndrome;VAS;MSQ;the proportion of responders;Self-Rating Depression Scale, SDS;